Cell Cycle and Apoptosis

Question 0

Checks replication and prepares for cell divison

Answer 0

G2

Question 1

Characterized by cell growth; checkpoint that prepares cell for replication

Answer 1

G1

Question 2

Cells continuously in the cell cycle

Answer 2

Labile Cells

Question 3

Cells in Go but may enter cell cycle

Answer 3

Quiescent/Stable Cells

Question 4

Cells which do not undergo cell cycle

Answer 4

Permanent Cells

Question 5

After crossing this barrier, cells are committed to DNA replication

Answer 5

Start/Restriction Point

Question 6

Stage of mitosis wherein aster formation punctures nuclear envelope

Answer 6

Prometaphase

Question 7

Glue that holds sister chromatids together

Answer 7

Cohesin

Question 8

Microtubule binding site on chromosome

Answer 8

Kinetochore

Question 9

Regulatory subunits whose concentration rises or lowers depending on stage in cell cycle

Answer 9

Cyclins

Question 10

Component of anaphase promoting complex that targets securin

Answer 10

Ubiquitin lyase

Question 11

Major checkpoints of the cell cycle

Answer 11

Restriction point, G2-M checkpoint, Anaphase checkpoint, checkpoint before cytokinesis

Question 12

TRUE/FALSE: phosphorylated CdKs are inactive

Answer 12

TRUE

Question 13

TRUE/FALSE: cells with stabilized cyclin exit into mitosis

Answer 13

FALSE

Question 14

Inhibitor of Separase

Answer 14

Securin

Question 15

Programmed cell death in which the cell actively participates in its own demise

Answer 15

Apoptosis

Question 16

Characteristics of apoptotic Cells

Answer 16

Shrink and condense, collapse of cytoskeleton, disassembled nuclear envelope, fragmentation of nuclear chromatin, blebbing of cell surface

Question 17

Apoptosis vs Necrosis

Answer 17

Apoptosis: self-programmed, self-contained cell death

Necrosis: spilling out of cellular contents, prominent in inflammation

Question 18

TRUE/FALSE: presence of death signals and lack of survival signals trigger apoptosis

Answer 18

TRUE

Question 19

Produced by certain cells of the immune system in response to adverse conditions; binds to death receptor that turns on apoptotic process

Answer 19

Tumor Necrosis Factor (TNF)

Question 20

Proteases that have cysteine in the active site and cleave target proteins with aspartic ends

Answer 20

Caspases

Question 21

Substance that triggers activation of executioner caspases in an amplifying proteolytic cascade

Answer 21

Caspase-8

Question 22

Term for cells in which apoptosis was halted and reversed

Answer 22

Anastasis

Question 23

Released from the mitochondria in the intrinsic pathway of apoptosis

Answer 23

Cytochrome C

Question 24

Death domains on cytosolic tails of the Fas death receptor that recruit intracellular adaptor proteins that recruit initiator caspases

Answer 24

Death-inducing signaling Complex (DISC)