Cartilage Flashcards

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1
Q

Where is cartilage located?

A

trachea, ear, respiratory tree and joints.

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2
Q

What is the mature cell type found in cartilage? what are they surrounded by? and what is located in this surrounding layer?

A

chondrocytes

perichondrium (immature firboblasts are here which mature to chondroblasts and further mature to chondrocytes)

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3
Q

is cartilage avascular or vascular?

A

avascular

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4
Q

What do chondrocytes contain?

A

lipids, glycogen, well developed RER (highly active in protein synthesis), golgi

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5
Q

Can cartilage regenerate quickly?

A

NO, limited mitosis.

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6
Q

What act as spacers for collagen?

A

PG (made up of GAGs and collagen)

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7
Q

Major difference between the matrix of cartilage and matrix of bone?

A

matrix of cartilage is NON mineralized and AVASCULAR.

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8
Q

What are the three main types of cartilage? which is the most common?

A

hyaline, elastic and fibrocartilage.

hyaline.

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9
Q

Where does hyaline cartilage normally get its blood supply from?

A

surrounding adipose tissue (highly vascular)

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10
Q

Where is hyaline cartilage found?

A

articular surfaces of joints, tracheal rings, bronchi, larynx, nose, rib cartilage.

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11
Q

two big characteristics of hyaline cartilage are?

A

resilience and pliability

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12
Q

What are isogenous groups?

A

cells located right next to one another because they have just recently divided.

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13
Q

what is a territorial matrix?

A

newer matrix, surrounds cells that have recently divided, close to one another.

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14
Q

what is an interterritorial matrix?

A

older matrix, around cells that have not recently divided.

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15
Q

What are two types of cartilage growth?

A
  1. appositional: cells growing from both ends and moving toward the center. main type of growth, more mature.
  2. interstitial: isogenous groups growing by mitosis, grows from center and moves outwards. during early growth/development
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16
Q

Main type of collagen in hyaline cartilage?

A

type 2

17
Q

territorial matrix often surrounds what type of groups?

A

isogenous

18
Q

What are lacunae?

A

holes in extracellular matrix where cells live, fluid filled.

19
Q

what are the two main components of the extracellular matrix in hyaline cartilage?

A

collagen 2 and PG.

20
Q

hyaline cartilage is normally surrounded by perichrondrium, what is the exception? what is the perichondrium made up of?

A
articular cartilage (around joints)
outer fibrous layer (fibroblasts here), inner chondrogenic layer (where chondroblasts are) and blood vessels.
21
Q

What differs between the extracellular matrix of elastic compared to hyaline?

A

elastic has similar matrix to hyaline but has elastic fibres and sheets (also has collagen type 2 and PGs)

22
Q

Where is elastic cartilage located?

A

ear, auditory canal, tube, epiglottis, larynx.

23
Q

Three main characteristics of elastic cartilage?

A

resilient, elasticity and pliability.

24
Q

is elastic cartilage avascular or vascular?

A

avascular

25
Q

what is elastic cartilage surrounded by?

A

perichondrium

26
Q

How are the chondrocytes arranged in fibrocartilage?

A

aggregates of small cells (fewer and smaller cells compared to other types), with many collagen one bundles

27
Q

what type of collagen is found in fibrocartilage?

A

type 1 AND type 2

28
Q

where is fibrocartilage located?

A

intervertebral discs, symphysis pubis, articular discs, menisci and tendon attachments.

29
Q

does firbocartilage have the perichondrium layer?

A

not in adults.

30
Q

what happens in arthritis? which type of cartilage is most prone?

A

calcification of articular cartilage (cartilage becomes bone usually during aging)
hyaline