Cardiopulmonary Pharmacology Flashcards
Alpha Adrenergic agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- Alpha Adrenergic antagonist agents reduce peripheral vascular tone by blocking alpha-1 adrenergic receptors. this action causes dilation of arterioles and veins and decreases blood pressure
- indication: hypertension, benign prostatic hyperplasia
- side effect: dizziness, palpitations, orthostatic hypotension, drowsiness
- implications: use caution when rising from a sitting or lying position due to the risk of dizziness and/or orthostatic hypotension. closely monitor patient during exercise
- example: cardura, minipress, hytrin
Angiotensin-Converting Enzyme ACE Inhibitor Agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- -Action: ACE inhibitor agents decrease blood pressure and afterload by suppressing the enzyme that converts angiotension I too angiotensin II
- Indication: hypertension, congestive heart failure
- Side effect: hypotension, dizziness, dry cough, hyperkalemia, hyponatremia
- implication for PT: Avoid sudden changes in posture due to the risk of dizziness and fainting from hypotension. Pt with heary failure should avoid rapid increases in physical activity
- examples: Capoten, vasotec, Prinvil, altace
Angiotensin II receptor antagonist agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- Action: block angiotensin II receptors which limit vasoconstriction and stimulation of vascular tissue
- Indication: hypertension, congestive heart failure
- Side effect: dizziness, back and leg pain, angina pectoris
- implication for PT: Minimal implications for PT
- examples: COzaar, Atacand. Diovan
4 classes for Antiarrhythmic Agents
- Class I sodium channel blockes
- CLass II beta blockers
- class III: potassium channel blockers
- Class IV: calcium channel blockers
CLass I antiarrhythmic agents
-Sodium channel blockers control cardiac excitation and conduction
Class II antiarrhythmic agents
- beta blockers- inhibit sympathetic activity by blocking B- adrenergic receptors
Class III antiarrhythmic agents
- potassium channel blockers
- prolong repolaarization by inhibiting both postassium and sodium channels and are often considered the most effective antiarrhythmic agents
Class IV antiarrhythmic agents
- clacium channel blockers
- depress depolarization and slow conduction through the AV node
antiarrhythmic agents
- Indication
- Side effect
- implication for PT
]-Indication: cardiac arrhythmias
- Side effect: Unique to the specific antiarrhythmic agent; exacerbation of cardiac arrhythmias, dizziness hypotension
- implication for PT: Encourage pt to adhere to teh prescribed dosing schedule and immediately report any adverse reactions to a healthcare professional
Anticoagulant agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- -Action: inhibit platelet aggregation and thrmobus formation
- Indication: post percutaneous transluminal coronary angioplasty and coronary artery bypass graft surgery, prevention of venous thromboembolism and cardioembolic events in pt with atrial fib and prosthetic heat valves
- Side effect: Hemorrhage, incr risk of bleeding, gastrointestinal distress with oral medication
- implication for PT: PT must be careful to avoid injury secondary to the risk of excessive bleeding or bruising. Pt education regarding common side effects is also indicated to protect the pt
- examples: heparin, coumadin (warfarin) , lovenox,
Antihyperlipidemia Agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- Action: the most commonly used drugs, the statins, inhibit enzyme action in cholesterol synthesis, break down low density lipoproteins decrease triglyceride levels, and increase HDL levels. the other categories are bile acid sequestrants, nicotinic acid, cholesterol absorption inhibitors, and fibric acid derivatives
- Indication: hyperlipidemia, atherosclerosis, prevent coronary events in patients with existing coronary disease, diabetes or PVD
-Side effect: HA, gastrointestinal distress, myalgia, rash
- implication for PT: Aerobic exercise can increase high density liporpoteins and maximize teh effects of drug therapy
- examples: lipitor, Zocor, Tricor
Antithrombotic Agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- Action: antithrombotic agnets inhibit platelet aggregation and clot formation
- Indication: post-myocardial infarction, atrial fib, prevent aterial thrombus formation
- Side effect: hemorrhage thrombocytopenia, potential liver toxicity with the use of aspirin, gastrointestinal distress
- implication for PT: PT must be careful to avoid injury secondary to the risk of excessive bleeding. Pt education regarding common side effects is also indicated to protect the patient
- examples: Bayer (aspirin), Plavix, persantine
Beta blocker agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- Action: decrease the myocardial oxygen demand by decreasing HR and contractility by blocking B- adrenergic receptors
- Indication: hypertension, angina, arrhythmias, heart failure, migraines, essential tremor
- Side effect: bradycardia, cardiac arrhythmias, fatigue, depression, dizziness, weakness, blurred vision
- implication for PT: HR and blood pressure response to exercise will be diminished. rate of perceived exertion may be used to monitor exercise intensity. closely monitor pt during positional changes due to an increased risk for orthostatic hypotension
-examples: tenormin,, lopressor, inderal
Calcium channel blocker
- Action
- Indication
- Side effect
- implication for PT
- examples
- Action: decrease the entry of calcium into vascular smooth muscle cells resulting in diminished myocardial contraction, vasodilation and decr oxygen demand of the heart
- Indication: hypertension, angina pectoris, arrhythmias, congestive heat failure
-Side effect: dizzness, HA, hypotension, peripheral edema
- implication for PT: HR and BP response to exercise will be diminished. monitor pt closely when moving to an upright position secondary to dizziness and/or orthostatic hypotension. observe the pt for signs and symptoms of congestive heart failure such as worsening peripheral edema, dyspnea, or weight gain
- examples: norvasc, procardia, calan, cardizem
Diuretic Agents
- Action
- Indication
- Side effect
- implication for PT
- examples
- Action: increase teh excretion of sodium and urine. this causes a reduction in plasma volume which decreases blood pressure. classifications include thiazide, loop, and potassium sparing agents
- Indication: hypertension, edema associated with heart failure, pulmonary edema, glaucoma
- Side effect: dehydration, hypotension, electrolyte imbalance, polyuria, increased low-density liproproteins, arrhythmias
- implication for PT: Positioning changes can increase the risk of dizziness and falls due to decr BP. monitor pt closely for S/S of electrolyte imbalance and muscle weakness or cramping
- examples: thiazide: diuril; loop:lasix; potassium sparing: dyrenium