Cardiology 2 Flashcards
What drug should all potential ACS patients be started on regardless of aetiology?
Aspirin 300mg
this is given regardless if it is actually an ACS
Name the two murmurs which are ejection systolic and louder on inspiration?
Pulmonary stenosis
Atrial septal defect
What is Bifurans pulse and what is it associated with?
When palpating the pulse there feels like a double pulse.
Anything aortic related can cause it: -
- aortic stenosis
- aortic regurgitation
- Obstructive cardiomyopathy
What is the criteria for angina?
Reproducible pain on exercise
Central chest pain
Relieved by GTN spray
What ambulatory home reading of BP do you always treat?
Any age over >150/95 you should treat
What is the management should thrombolysis fail?
If still symptomatic and ST elevation stil present then PCI should be conducted
In the setting of a suspected P.E, if a CTPA comes back negative, what should the next investigation be?
US of the proximal legs to search for DVT
Which drug is contraindicated in VT?
Calcium channel blockers
- reduces contractibility too much
If a pateint is unstable with Fast AF and has signs of ischemia (ST elevation) what is your initial management?
DC Cardioversion
- you cannot start PCI etc without first stabilising rhythm
What is the S3 sound and S4 Sound?
S3: Abnormal flow of blood into an already distended ventricle. Sound of turbulence as two bodies of blood mix
- first sound of heart failure
S4: A atrium struggling to force blood into a stiff ventricle during late diastole. The ventricle does not want to stretch.
- often heard alongside an S3 which causes a galloping rhythm
What type of splitting is heard in Atrial septal defect?
Fixed splitting of second heart sound
What are the two broad aetiologies of a wide splitting of S2?
Delay in P2 closure:
- RBBB
- Pulmonary stenosis
Early closure of A2:
- Mitral valve regurgitation
- Ventricular septal defect
What is a useful mnemonic for remember CHA2DS2VACS score?
A score used to assess the need for anti-coagulation. Often used in the context of AF.
Mnemonic: SADCHAVS - Stroke (2 points) - Age 75 (2 points) - Diabetes - Congestive heart failure - Hypertension - Age 65 - Vascular history - Female
What is the complication that can occur with a inferior STEMI leading to bradycardia:
third degree heart block
- QRS may be narrow or wide depending where the escape rhythm is
List some common viruses which cause pericarditis:
Coxsackieviruse virus
Mumps
Rubella
Hep B
What are some risk factors for aortic dissection?
Atherosclerotic aneurysm disease
Smoking
Ehler’s -Danlos syndrome
Marfan’s syndrome
Co-arctation
What is the diagnostic test of choice for a suspected aortic dissection, and what test can be done if the patient is not stable enough?
CT angiogram of Chest/ Abdomen/ Pelvis
TOE should be conducted if too unstable
How should an aortic dissection be managed?
Type A:
- Oxygen
- IV access - with bloods off
- IV labetalol to reduce Blood pressure
- try stabilise blood pressure to 100-120mmHg
- GTN
- Morphine
*open surgery or endovascular graft stent repair
Type B:
- Bed rest
- Labetalol blood pressure control
What are some of the complications of aortic dissection?
Aortic regurgitation
M.I
Peripheral ischemia
- AKI
- Mesenteric
Paralysis
- anterior spinal artery can be compromised
What is the wave called in WPW syndrome?
Delta wave
*there is also a reduced PR interval
What heparin is given for NSTEMI and for STEMI?
LMWH for NSTEMI
Unfractionated for STEM
What are the general aetiologies of the heart block?
Type I and Mobitz type I are medical causes
Type II Mobitz and third degree heart block are structural due to ischemia usually
When are U waves seen?
Hypokalaemia
Bradycardia
- can be seen as a normal in certain individuals
What are the indications for CABG, where should you look for scars and what vessels may be used?
Indications:
- Triple vessel disease
- Critical left main stem disease (>50% stenosis)
- Heart failure/ poor LV function
Midline sternotomy scar.
Saphenous scar.
Other vessels which may be used:
- Left Internal mammary artery (LIMA)
What are the common complications of CABG?
Bleeding Arrhythmia Stroke Poor cardiac output Wound infections
What may occur in endocarditis which leads to bradycardia?
Abscess formation
- compressing on the AV node leading to heart block
What drugs are given for hyperkalaemia and what are the ECG findings?
Calcium carbonate - 10% in 10mls over 10mins
Salbutamol
Insulin and Dextrose
Calcium resonium for absorptions
ECG:
- tall tented T waves
- PR elongation
- Widening of QRS
- Sinusiodol wave formation
What are some causes of hyperkalaemia?
Renal Failure K+ sparing drugs Rhabdomyolysis Metabolic Acidosis Massive blood transfusion Addison's disease
What features would make PCI non-favourable?
Extreme stenosis
Tortuous vessels
Blockage near entrance to vessel
What are the causes of mitral valve prolapse following an M.I and how is it diagnosed?
M.I of posterior wall causing dysfunctional papillary muscle
M.I of papillary muscle
TOE is needed for diagnosis and urgent surgery is required.
What are the types of M.I and list several things that can increase you’re troponin not related to an M.I:
Type: I - thromboembolic Type II - Arrhythmias, high output Type III - Sudden death Type IV - PCI Type V - Surgery related
Troponin rises:
- Chronic renal failure
- Sepsis
- P.E
- Tachyarrhythmias
- Aortic dissection
What is the classification system used to assess heart failure in patients post M.I and list some other common complications following an M.I:
Killip classification
- prognostic indicator of heart failure following an M.I
Common complications:
- Myocardial Rupture
- VSD
- Arrhythmias
- Mitral regurgitation
- Dressler’s syndrome
- Psychological effect
Where do the coronaries branch off the aorta?
Aortic sinuses
- just above the valves
What is the definitions of a STEMI?
ST elevation of >2mm in chest leads, 1mm in limb leads
or
New Left Bundle branch block
**this is why its so important to look at previous ECGs
What other biochemical markers could be tested for in ACS other than troponins?
CK
LDH
Advice to patient post M.I?
Cardiac rehabilitation Smoking cessation Diet Work return in 1-2 months Driving 4 weeks (unless PCI where 1 week) Vigorous exercise is graded Sex - 2/4 weeks
What blood tests and investigations do you want into AF?
FBC - infection?
U&Es - Electrolyte dysfunction?
Troponins - Ischemia/ M.I?
TFTs - Thyrotoxicosis
CXR - pneumonia causes it?
Echocardiogram
- assess for chamber sizes and valvular pathologies
If a patient is unstable with AF - what is the management?
DC cardioversion
- irrespective of Anti-coagulation
- do not delay in order to anti-coagulate
*if clinical appropriate a TOE can be conducted to assess
What are the types of AF?
Acute onset <48 hours
Chronic:
- Paroxysmal (<7 days but reoccurs)
- Persistent (>7 days and reoccurs)
- Permanent (never goes away)
What is the newyork classification of heart failure?
I: Heart disease present but no symptoms
II: Comfortable at rest. dysnpea on normal activities
III: Comfortable at rest but marked symptoms on mimimal activities
IV: Dyspnea at rest
List 4 features of Left ventricular heart failure:
Fatigue Dyspnea Paroxysmal nocturnal dyspnea Orthopnea Cardiac wheeze Frothy - sputum/ cough
What hormone is significantly risen in heart failure?
NT - Pro-BNP
Electrolyte abnormalities of Furosemide?
Hypo:
Na2+/ K+/ Ca2+/ Mg+
Hyperucaemia
What two electrolyte abnormalities does Digoxin cause?
Hyperkalamia
Hyponatramia
Metabolic acidosis
What are some important abnormal waves to be aware of in the JVP?
Large A wave
- Fullness in atrium (HF, pulmonary stenosis)
Large V wave (last wave)
- Tricuspid regurgitation
How would you investigate ischemic heart disease/ Angina?
ECG CT angiogram - 1st line investigation Functional imaging - stress echo - Cardiac MRI
Bloods
- FBC
- U&Es
- Lipids
- HbA1c
- TFTs
What are the findings on ECG of WPW syndrome? and how is it managed?
ECG findings:
- upsloping QRS - delta wave
- Shortened PR
- Flipped T wave
- note that it may only appear with SVT and need to be slowed to be seen
Management:
- Radio ablation - definitive
medical Management:
- amiodarone
- Flecainide
- beta blockers (which are contraindicated if AF)
What are the specific leads of the chest?
V1 - V2 = septal leads
V3-V4 = Anterior Leads
V5- V6 = Lateral leads
*typically V1-V4 are called the anterior-septal leads
What are the indications for a heart transplant in the setting of heart failure?
Severe functional impairment
Dependence on IV inotropic
Recurrent life threatening arrhythmias
Angina not responding to any medical therapy
Why does the thickness of the heart increase in heart failure?
Laplace’s Law:
Decreases tension.
Equation is:
Tension = Pressure x Radius / Thickness
increased pressure due to increased volume and reduced ability to get rid of fluid. therefore increase the thickness reduces the tension
Define heart failure:
Abnormal cardiac function which results in the inability of the heart to meet the metabolic needs of the body resulting in:
- breathlessness
- Fatigue
- Oedema
When starting sacubitril and valsartan what must be done with a particular medication?
Discontinue ACE inhibitor
List some signs of heart failure:
Orthopnoea Paroxysmal nocturnal dyspnoea Oedema Hepatomegaly Ascites Raised JVP Displaced Lateral Apex beat - ventricular enlargement Gallop rhythm (S3 and S4)
List some causes and signs of Pulmonary hypertension:
Pulmonary hypertension >25mmHg
- idiopathic
- Connective tissue disease
- Chronic lung disease (remodels the epithelium increasing resistance)
- Left sided heart failure (systolic dysfunction)
- ASD/ VSD
- Haemolotolgical disease (polycyethmia)
Signs:
- Congestion signs (JVP, hepatomegaly etc)
- left parasternal heaves
- Loud P2 (pulmonary valve snapping shut)
- Soft Pansystolic murmur (tricuspid regurgitation)
What are some causes of reduced ejection fracture and preserved ejection fracture heart failure?
Reduced ejection fracture:
- Ischaemic heart disease (atherosclerosis)
- Post M.I
- Dilated cardiomyopathy
- younger patients
- males
Preserved ejection fracture:
- Long term hypertension
- Aortic stenosis
- obstructive cardiomyopathy
- constrictive cardiomyopathy
- older patients
- females