Cardio 1 Flashcards
what is the most common valve affected in endocarditis
+ name order of most to least common valves affected
mitral MC
M > A > T > P
tricuspid in drug users
what is the MC overall cause of endocarditis
strep viridans
MCC acute bacterial endocarditis and what valves are affected
staph aureus - normal valves
MCC subacute bacterial endocarditis and what valves are affected
S viridans - abnormal valves
MCC drug-related endocarditis
S aureus (especially MRSA)
MCC prosthetic valve endocarditis
early (within 60 days) = S aureus (including MRSA) and s. epidermidis
MCC endocarditis if recent GI or GU procedure
enterococcus
HACEK organisms + what type of organisms
haemophilus aphrophilus
actinobacillus
cardiobacterium hominis
eikenella corrodens
kingella kingae
these are gram negative organisms, hard to culture
sx endocarditis (FROM JANE)
fever
rosh spots
osler nodes
murmur
laneway lesions
anemia
spliNter hemorrhages
emboli
what are the 2 most important tests for suspected endocarditis
blood cultures and echo (obtain TTE first –> TEE)
what criteria is used to diagnose endocarditis
duke criteria
major duke criteria
sustained bacteremia - 2 + blood cultures by organism known to cause endocarditis
endocardial involvement documented by either echo (vegetation, abscess, valve perforation, prosthetic dehiscence) or clearly established new valvular regurgitation (aortic or mitral regurgitation)
minor duke criteria
predisposing conditions - abnormal valves, IVDA, indwelling catheters
fever (100.4F)
vascular and embolic phenomena
+ cultures not meeting major criteria
+ echo not meeting major criteria (worsening existing murmur)
how to diagnose endocarditis with duke criteria
2 major or 1 major + 3 minor or 5 minor
treatment for native valve (MSSA) endocarditis
native valve (MRSA) or unknown
prosthetic valve
fungal
native MSSA - nafcillin, oxacillin
native MRSA or unknown - vancomycin + cef or gentamicin
prosthetic valve - vancomycin + gentamicin + rifampin
fungal - parenteral anti fungal (amphotericin, can add flucytosine)
how long is therapy for endocarditis
4-6 weeks
what is the worst risk factor for angina
DM
diagnosing angina
EKG - initial test of choice, ST depression
Stress testing - most important noninvasive
coronary angiography - definitive; defines location and extent
what is used for definitive diagnosis of angina
coronary angiography
treatment for angina
outpatient - aspirin, beta blockers, nitroglycerin, statin
Revascularization with PCI or CABG = definitive
when to do PCI vs CABG for angina
PCI - 1 or 2 vessel disease in non diabetes NOT involving left main coronary artery
CABG - left main coronary artery stenosis, 3 vessel disease, decreased LVEF < 40%, 2 vessel disease in DM
unstable angina is characterized by what 3 things
1) sx suggestive of ACS
2) negative cardiac biomarkers (negative CK and troponin)
3) with or without EKG changes suggestive of ischemia (ST segment depressions or new T waves)
what is the MCC of unstable angina
plaque rupture
when is angina considered “unstable”
rest angina lasting > 20-30 minutes
new-onset angina
change in anginal pattern
not relieved with rest or nitroglycerin
treatment for unstable angina
aspirin, beta blockers, oxygen if hypoxic
aspirin + P2Y12 inhibitor
anticoagulant