Carcinoid Tumors Flashcards
What is a carcinoid tumor?
Tumor arising from neuroendocrine cells (Kulchitsky cells).
Secretes serotonin.
Why is a carcinoid tumor called “carcinoid”?
A carcinoid resembles a carcinoma but is clinically and histologically less aggressive than most GI carcinomas
How can you remember that Kulchitsky cells are found in carcinoid tumors?
KUL CAR
What are the common sites for carcinoid tumors?
AIR:
Appendix, Ileum, Rectum
Also bronchus, jejunum, stomach, duodenum, colon, ovary, testicle, pancreas, thymus
What are the signs and symptoms of a carcinoid tumor?
Depends on the location (most cases are asymptomatic).
SBO, abdominal pain, bleeding, weight loss, diaphoresis, pellagra skin changes, intussusception, carcinoid syndrome, wheezing
Why SBO with carcinoid?
Severe mesenteric fibrosis
What are the pellagra-like symptoms of a carcinoid tumor?
- Dermatitis
- Diarrhea
- Dementia
What causes pellagra in carcinoid patients?
Decreased niacin production
What is carcinoid syndrome?
Syndrome of symptoms caused by release of substances from a carcinoid tumor
What are the symptoms of carcinoid syndrome?
B FDR:
Bronchospasm, Flushing (skin), Diarrhea, Right-sided heart failure (from valve failure)
Why does right-sided heart failure develop but not left-sided heart failure in carcinoid syndrome?
Lungs act as a filter, thus the left heart doesn’t see all the vasoactive compounds
What is the incidence of carcinoid syndrome in patients with a carcinoid tumor?
10%
What released substances cause carcinoid syndrome?
Serotonin and vasoactive peptides
What is the medical treatment for carcinoid syndrome?
Octreotide IV
What is the medical treatment of diarrhea alone in carcinoid syndrome?
Odansetron (Zofran)