Cannabis

Question 1

What is cannabis primarily derived from?

Answer 1

Cannabis sativa plant

A member of the hemp family

Question 2

How long has cannabis been cultivated?

Answer 2

At least 4500 years

Originated in Central Asia

Question 3

What are the three main constituents of cannabis?

Answer 3

• Tetrahydrocannabinol (THC)
• Cannabidiol
• Cannabinol

Question 4

Which cannabinoid is considered the main active compound?

Answer 4

Tetrahydrocannabinol (THC)

First isolated and identified in 1964

Question 5

What are the two types of cannabinoid receptors?

Answer 5

• CB1
• CB2

Question 6

Where are CB1 receptors primarily located?

Answer 6

In the brain

Involved in consciousness, memory, coordination, and more

Question 7

What physiological effect does THC have on the mood?

Answer 7

Relaxation and sense of well-being

Similar to ethanol effects without aggression

Question 8

What is the significance of anandamide in the context of cannabinoids?

Answer 8

It is the first endogenous cannabinoid discovered

Mimics the effects of cannabinoids

Question 9

Fill in the blank: The discovery of cannabinoid receptors was made in _______.

Answer 9

1988

Question 10

What are some clinical applications of cannabinoid drugs?

Answer 10

• Nausea and vomiting in cancer chemotherapy
• Weight loss in cancer and AIDS
• Glaucoma treatment
• Multiple sclerosis
• Pain management
• Anxiety

Question 11

What is the potential use of rimonabant?

Answer 11

Treating obesity by blocking endocannabinoid stimulation of appetite

Early data suggests effectiveness

Question 12

What are some short-term adverse effects of cannabinoid receptor stimulation?

Answer 12

• Euphoria
• Drowsiness
• Sensory distortion
• Loss of short-term memory

Question 13

True or False: Long-term use of cannabinoids is universally accepted to be safe.

Answer 13

False

Long-term usage may induce psychological problems

Question 14

What is the ‘gateway theory’ in relation to cannabis?

Answer 14

It suggests that use of cannabinoids may stimulate needs for stronger, more addictive drugs

Question 15

What historical use of cannabis was noted during WWII?

Answer 15

Used as a truth serum

Developed by a US intelligence agency

Question 16

What are the two distinct strategies for clinical applications of cannabinoids?

Answer 16

• Activation of the cannabinoid receptor
• Inhibiting the cannabinoid receptor

Question 17

What role do endocannabinoids play in the body?

Answer 17

Modulate several key physiological activities

Includes cardiovascular function, pain regulation, and appetite

Question 18

Which cannabinoid is known to be a precursor for THC?

Answer 18

Cannabidiol

Question 19

What effect does THC have on the digestive system?

Answer 19

Reduces nausea and vomiting, stimulates appetite

Question 20

What is a major concern regarding the long-term effects of cannabinoid treatment?

Answer 20

Potential psychological disturbance

Ongoing research is needed

Question 21

Fill in the blank: Cannabinoids were historically used in the 1940s as a _______.

Answer 21

Truth serum

Question 22

What was Queen Victoria’s personal doctor’s claim about cannabis in 1890?

Answer 22

Cannabis is one of the most valuable medicines we possess

Question 23

What is the primary cannabinoid found in the resin of the cannabis plant?

Answer 23

THC