Canine Parvovirus (Exam 2)

Question 1

Canine Parvovirus is a (small/large), (enveloped/non-enveloped), (ssDNA/ssRNA/dsDNA/dsRNA) virus.

Answer 1

small non-enveloped ssDNA

Question 2

(T/F) Canine Parvovirus is zoonotic.

Answer 2

False

Question 3

(T/F) Canine Parvovirus-1 is the concerning, life-threatening strain of parvovirus.

Answer 3

False (2!!!)

Question 4

Canine Parvovirus-2 causes what two major conditions?

Answer 4

enteritis
myocarditis

Question 5

Canine Parvovirus-2 is a result of a mutation of _____________ virus.

Answer 5

Feline Panleukopenia

Question 6

(T/F) Dogs and wild animals such as foxes, coyotes, and wolves can be affected by Canine Parvovirus-2, but is it most severe in young puppies.

Answer 6

True

Question 7

(T/F) Canine Parvovirus-2 can infect cats.

Answer 7

True - can shed virus and similar to panleukopenia

Question 8

(T/F) Cats vaccinated for Feline Panleukopenia Virus receive cross-protection against CPV-2.

Answer 8

True

Question 9

What is the primary sign of Canine Parvovirus?

Answer 9

diarrhea

Question 10

Canine Parvovirus causes (diffuse/segmented) infection of the intestines.

Answer 10

segmented

Question 11

Which variant of CPV is a common isolate which causes enteritis to dogs in the US?

Answer 11

CPV-2b

Question 12

(T/F) Vaccines for CPV are effective against all strains and the tests detect all known variants.

Answer 12

True

Question 13

How is Canine Parvovirus transmitted?

Answer 13

feces or fomites

Question 14

Canine Parvovirus can survive in the environment for up to ____ months and is resistant to __________.

Answer 14

5
disinfectants

Question 15

What phase of the cell cycle does Canine Parvovirus require for replication in the host cell nucleus?

Answer 15

S phase

Question 16

Canine Parvovirus first infects lymphoid tissue of the oropharynx and replicates in the host nucleus. Then _________ occurs 1-5 days after infection.

Answer 16

primary viremia

Question 17

After primary viremia, Canine Parvovirus infects ________ epithelium and eventually, _____ necrosis leading to diarrhea.

Answer 17

crypt

Question 18

What is the incubation period of CPV?

Answer 18

7-14 days

Question 19

(T/F) CPV is not actively shed until the onset of diarrhea.

Answer 19

False - before onset

Question 20

Myocarditis develops with CPV without sufficient ________ around 3 weeks of age.

Answer 20

maternal antibody

Question 21

_________ is a diagnostic method used for CPV in hospital, however false negatives are possible and the modified-live vaccine causes a false positive 5-12 days post-vaccination.

Answer 21

ELISA

Question 22

For serology, ______ levels are not very useful for CPV diagnosis as they go up after viral replication stops.

Answer 22

IgG

Question 23

What disinfectant is used for CPV?

Answer 23

diluted household bleach (1:30) for 10 min

Question 24

Puppies with CPV should not go to any dog parks, kennels, or other locations with high dog volume until __________.

Answer 24

fully vaccinated

Question 25

What is the most common cause of vaccination failure in puppies?

Answer 25

blocking by maternal antibodies

Question 26

Canine Coronavirus is a(n) (enveloped/nonenveloped) (RNA/DNA) virus.

Answer 26

enveloped RNA

Question 27

Canine Coronavirus is (resistant/sensitive) to change in temperature and (resistant/sensitive) to disinfectants.

Answer 27

resistant
sensitive

Question 28

Canine Coronavirus is a (core/noncore) vaccine.

Answer 28

non-core (may be recommended in kennels)

Question 29

CPV testing in a diagnostic lab is more accurate for diagnosis. Which two tests are used?

Answer 29

histopath
PCR

Question 30

ELISA is (more/less) sensitive than PCR for CPV.

Answer 30

less (send it out if negative!)

Question 31

In dogs 6 weeks and older, the predominant clinical signs of CPV are:

Answer 31

enteritis + leukopenia

Question 32

Canine Coronavirus replicates in what cell type?

Answer 32

enterocytes