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PoD Test 3 > Cancer Chemotherapy 2 > Flashcards

Cancer Chemotherapy 2 Flashcards

1
Q

What is the MoA of Fluorouracil?

A

Inhibits thymidylate synthase, decreasing DNA synthesis

Incorporated into DNA and RNA

CCNS

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2
Q

What are the unique toxicities of fluoruracil?

A

Oral and GI ulceration

Stomatitis and diarrhea

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3
Q

What is the MoA of Cytarabine?

A

Inhibits DNA Pol a

CCS - S phase

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4
Q

What is the MoA of Gemcitabine?

A

Inhibits DNA synthesis via many mechanisms

Active form is dFdCTP

CCNS

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5
Q

What are the adenosine deaminase inhibitors?

A

Pentostatin

Cladribine

Fludarabine

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6
Q

What is the MoA and use of adenosine deaminase inhibitors?

A

Causes build up of adenosine and deoxyadenosine nucleotides decreases DNA synthesis

Hairy cell leukemia and other leukemias and lymphomas

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7
Q

What is the MoA of vinca alkaloids?

A

Bind specifically to soluble tubulin, blocking polymerization

CCS - M phase

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8
Q

What are the unique toxicities of vinca alkaloids?

A

Peripheral neuropathy

Alopecia

Nephrogenic SIADH

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9
Q

What is the Moa of Yew alkaloids?

A

Paclitaxel/Docetaxel

Prevents microtubule depolymerization

CCS - M phase

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10
Q

What is the unique toxicity of yew alkaloids?

A

Peripheral neuropathy

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11
Q

What is the MoA of Mitotane?

A

Blocks hormone productiong by the adrenal gland, destroys both adrenal cancer cells and healthy cells

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12
Q

What are the side effects of mitotane?

A

Fatigue and nausea

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13
Q

What is the MoA of Interferons?

A

Inhibits tumors by regulating host immune system of patient

CCNS

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14
Q

What cancers is prednisone for?

A

Hodgkin’s disease

Acute leukemias

Relapsed hairy cell leukemia

Manage hemolytic anemia

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15
Q

What is the MoA of progestins?

A

Used in hormone responsive cancers expressing progesterone receptor

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16
Q

What is the MoA of Tamoxifen, toremefine?

A

Used in estrogen receptor positive breast cancer

17
Q

What is the MoA of Anti-Adrogens?

A

Bicalutamide, Flutamide, Nilutamide

Blocks androgen-induced growth

Normally combines with leuprolide (LHRH agonist)

18
Q

What is the MoA and Unique toxicity of Bevaczimab (Avastin)?

A

Blocks VegF and prevents angiogenesis

ADR: Impaired wound healing, hemorrhage, thrombosis

19
Q

What is the MoA and unique toxicity of Denusomab?

A

Blocks Rank-rank ligand in bone

ADR: Dermatitis, propensity for infections

20
Q

What is the MoA and unique toxicity of Trastuzumab?

A

Blocks Her2/c-Neu

Hepatotoxicity, Pulmonary toxicity, rash

21
Q

What is the MoA and unique toxicity of Rituximab?

A

Blocks CD20 on B-cells

Headache, fever, diarrhea

22
Q

What is the R-CHOP regimen?

A

First line treatment of B-cell Non-hodgkin lymphoma

Rituximab, Cyclophosphamide, Doxorubicin, Vincristien, Prednisolone

23
Q

What is the MoA, use, and toxicity of Ipilimumab and Tremelimumab?

A

Blocks CTLA4

Metastatic melanoma

Colitis, Diarrhea, Skin rash

24
Q

What is the MoA, use, and toxicity of Nivolumab and Pembrolizumab?

A

Blocks PD-1

Metastatic melanoma

Fatigue, colitis, rash

25
Q

What is the MoA of Imatinib?

A

Blocks Bcr-Abl kinase

26
Q

What is the MoA of erlotinib and ggefitinib?

A

Blocks EGFR signaling

27
Q

What is the MoA of Crizotinib?

A

Blocks ALK-1 kinase

28
Q

What is the MoA of Venetoclax and its use?

A

Binds to Bcl-2 and inhibits its anti-apoptotic activity

Refractory chronic lymphocytic leukemia

29
Q

What are the HDAC inhibitors?

A

Vorinostat and Romidepsin

30
Q

What is the MoA of Olaparib?

A

Inhibits PARP-1, impairing the DNA repair process

31
Q

What is amirubicin?

A

Anthracycline

Reduced cardiotoxicity

32
Q

What is Fluvestrant?

A

ER blocker, lacks partial estrogen activity

Used for estrogen responsive cancers

33
Q

What is abraxane?

A

Intravenous nanoparticle

Cremophor-free

34
Q

What is picoplatin?

A

Organic platinum containing chemotherapy

Doesn’t cause platinum resistance

PoD Test 3 (25 decks)

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