Cancer Associations Flashcards
BCR-ABL
Tyrosine kinase - CML and AML
oncogene
BCL-2
Antiapoptotic molecule - holds back BAX
Follicular lymphoma
Oncogene
BRAF
Serine threonine kinase
Oncogen
Melanoma and Non hodgkins lymphoma
C-KIT
Cytokine receptor
oncogene
GIST - gastrointestinal stromal tumor
C-MYC
Transcription factor
oncogene
Burkitt Lymphoma
Her2/Neu
Tyrosine kinase
oncogene
breast, ovarian, gastric
L-myc
TF
oncogene
lung tumor
N-MYC
TF
oncogene
neuroblastoma
RAS
GTP-ase
oncogene
colon, lung, pancreatic
RET
TK
Oncogene
MEN2A MEN2B Medullary (calcitonin) thyroid cancer
APC
TS
Targets beta-catenin to be destroyed (beta catenin (over expression of beta catenin leads to cell proliferation)
Colorectal cancer (associated with FAP)
BRCA1/BRCA2
TS
DNA repair protein
breast and ovarian cancer
DCC
TS
Deleted in colon cancer
colon cancer
DPC4/SMAD4
TS
Deleted in pancreatic cancer
pancreatic cancer
MEN1
TS
Menin
MEN1
NF1
TS
Ras GTPase acitivating protein (neurofibromin)
NFB1
NF2
TS
Merlin (schwannomin protein)
NF2
P16
TS
Cyclin-dependent kinase inhibitor 2a
melanoma
p53
TS
Transcription factor for p21, blocks G1->S
Most human cancers, Li Fraumeni
PTEN
TS
Breast, prostate, endometrial
Rb
TS
Inhibits E2F; Blockst G1-S
Retinoblastoma; osteosarcoma
TSC1 and TSC2
TS
Harmartin and Tuberin protein respectively
Tuberous sclerosis
VHL
TS
Inhibits Hypoxia inducible factor 1a - which makes vegf go - which bring new bvs
von Hippel-Lindau ; renal cell carcinoma
WT1/WT2
TS Wilms tumor (nephroblastoma)
