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0001 STEP ONE RAPID REVIEW DX > Cancer Associations > Flashcards

Cancer Associations Flashcards

1
Q

BCR-ABL

A

Tyrosine kinase - CML and AML

oncogene

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2
Q

BCL-2

A

Antiapoptotic molecule - holds back BAX
Follicular lymphoma
Oncogene

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3
Q

BRAF

A

Serine threonine kinase
Oncogen
Melanoma and Non hodgkins lymphoma

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4
Q

C-KIT

A

Cytokine receptor
oncogene
GIST - gastrointestinal stromal tumor

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5
Q

C-MYC

A

Transcription factor
oncogene
Burkitt Lymphoma

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6
Q

Her2/Neu

A

Tyrosine kinase
oncogene
breast, ovarian, gastric

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7
Q

L-myc

A

TF
oncogene
lung tumor

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8
Q

N-MYC

A

TF
oncogene
neuroblastoma

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9
Q

RAS

A

GTP-ase
oncogene
colon, lung, pancreatic

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10
Q

RET

A

TK
Oncogene
MEN2A MEN2B Medullary (calcitonin) thyroid cancer

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11
Q

APC

A

TS
Targets beta-catenin to be destroyed (beta catenin (over expression of beta catenin leads to cell proliferation)
Colorectal cancer (associated with FAP)

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12
Q

BRCA1/BRCA2

A

TS
DNA repair protein
breast and ovarian cancer

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13
Q

DCC

A

TS
Deleted in colon cancer
colon cancer

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14
Q

DPC4/SMAD4

A

TS
Deleted in pancreatic cancer
pancreatic cancer

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15
Q

MEN1

A

TS
Menin
MEN1

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16
Q

NF1

A

TS
Ras GTPase acitivating protein (neurofibromin)
NFB1

17
Q

NF2

A

TS
Merlin (schwannomin protein)
NF2

18
Q

P16

A

TS
Cyclin-dependent kinase inhibitor 2a
melanoma

19
Q

p53

A

TS
Transcription factor for p21, blocks G1->S
Most human cancers, Li Fraumeni

20
Q

PTEN

A

TS

Breast, prostate, endometrial

21
Q

Rb

A

TS
Inhibits E2F; Blockst G1-S
Retinoblastoma; osteosarcoma

22
Q

TSC1 and TSC2

A

TS
Harmartin and Tuberin protein respectively
Tuberous sclerosis

23
Q

VHL

A

TS
Inhibits Hypoxia inducible factor 1a - which makes vegf go - which bring new bvs
von Hippel-Lindau ; renal cell carcinoma

24
Q

WT1/WT2

A 
TS
Wilms tumor (nephroblastoma)

0001 STEP ONE RAPID REVIEW DX (25 decks)

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