Bullous Disorders

Question 0

What are the variants of Pemphigus Foliaceus?

Answer 0

1. Idiopathic (most common)
2. Endemic
3. Drug induced
4. Erythematous

Question 1

What are the types of Pemphigus Vulgaris and where do they occur?

Answer 1

1. Mucosal Pemphigus Vulgaris–always oral lesions

2. Mucocutaneous Pemphigus Vulgaris–midface and scalp

Question 2

What does Paraneoplastic Pemphigus affect?

Answer 2

Desmosomes and hemidesmosomes

Question 3

What is Nikolsky sign?

Answer 3

1. Pressing down on the blister makes them larger and spread out because they are so tough.
2. Associated with Bullous Pemphigoid

Question 4

What does Epidermolysis Bullosa Acquista affect?

Answer 4

Type VII collagen

Question 5

What causes Dermatitis Herpetiformis?

Answer 5

Gluten sensitivity

Question 6

What are the three classes of Epidermolysis Bullosa?

Answer 6

1. Simplex (epidermolytic) (AD)
2. Junctional (AR)
3. Dystrophic (dermolytic) (AR/AD)

Question 7

What is the most likely form of Epidermolysis Bullosa Simplex we will see in the foot?

Answer 7

Localized (Weber-Cockayne)

Question 8

What disorders affect Type VII collagen?

Answer 8

1. Epidermolysis Bullosa Acquista

2. Dystrophic Epidermolysis Bullosa

Question 9

What is the most common form of Porphyria?

Answer 9

Porphyria Cutanea Tarda

Question 10

What differentiates Porphyria from Pseudo-porphyria?

Answer 10

Pseudo-porphyria has normal levels of prophyrin