Non-Pigmented, Malignant Non-epithelial (Sarcomas)

Question 0

Myxoinflammatory Fibroblastic Sarcoma

Answer 0

1. Cells look like RS cells (owl eye nuclei)

2. Involves toes

Question 1

Atypical Fibroxanthoma

Answer 1

1. Pink papule/nodule –> ulceration

2. Spindle cell variant (middle aged women) –> common in LE

Question 2

Dermatofibrosarcoma Protuberans

Answer 2

1. Begins in dermis and makes hard potato like nodules

2. Bednar tumors (subtype)

Question 3

Leiyomyosarcoma

Answer 3

1. Low or high grade

2. <12 months with metastasis

Question 4

Liposarcoma

Answer 4

1. Arising in distal extremity –> Atypical Lipomatous Tumor

2. Very malignant

Question 5

Kaposi’s Sarcoma

Answer 5

1. Misnomer, not sarcoma, its hyperplasia
2. Variants
   a. Classic–commonly in LE, good prognosis
   b. Epidemic–HIV association, mucosal, deadly
   c. Endemic–lymphadenopathic, always deadly
   d. Immunosuppresant–transplant associated, seen in LE

Question 6

Angiosarcoma

Answer 6

1. LG –> Hemangioendothelioma (good prognosis)

2. HG (poor prognosis)