Bone and Soft Tissue Flashcards
Brittle bone disease?
Osteogenesis Imperfecta
1) Type 1 collagen?
2) type 2 collagen?
3) type 2 hypersensitivity?
1) Osteogenesis Imperfecta
2) osteoarthritis
3) myasthenia gravis
Treatment of osteoporosis?
- Calcium and Vit D supplementation
- Weight bearing exercise
- Biphosphonates - decrease osteoclast-mediated bone resorption.
defective dentin in Osteogenesis Imperfecta is called?
dentinogenesis imperfecta
3 phases of development of Paget’s disease and fibrous dysplasia?
1) Osteoclastic: bone loss, hypervascularity
2) Osteoclastic and osteoblastic
3) Osteoblastic: formation of dense, mineralized bone
Most of Paget’s are monostotic or polyostotic?
polyostotic
1) 1 to 2.5 is?
2) below 1 is?
1) osteopenia
2) osteoporosis
Osteomyelitis casued by what bacteria?
Actinomycosis
New bone around dead bone is called?
involucrum
DEG stands for?
Drugs, Endocrine (thyroid), Gastric malnutrition (Vit D)
*** osteoporosis!
sequestra
dead bone
Paget’s has elevated _____ and normal levels of?
elevated serum alkaline phosphatase due to increased osteoblastic activity
•Serum calcium and phosphate are normal
What drugs inhibit osteoclast activity?
Prolia and bisphosphanate!
- osteoclast has RankL
- Osteoblast has RANK
APC gene
Gardners Syndrome
Osteogenesis Imperfecta
- autosomal dominant
- Brittle bone disease
- Blue sclera, dentinogenesis imperfecta, hearing loss
Osteopetrosis
- reduced osteoClast activity
- defective REMODELING! Bone calcification ok
- bone densitity or radioopaque
- CN probs due to compression
obliteration of bone marrow in osteopetrosis causes/
- Reduced hematopoiesis
- Recurrent infections
- Normocytic anemia
Osteoporosis is caused by?
**Idiopathic or secondary to?
menapuasal woman!
**Idiopathic or secondary to corticosteroids or multiple
myeloma
onion
chronic osteomyelitits (children) OR ewing sarcoma
F > M
- giant cell tumor (brown’s tumor)
- osteoporosis
- myasthenia gravis
- fibrous dysplasia
Ewings syndrome mimics?
osteomyelitis
Paget’s Disease/ Osteitis
Deformans is associated with what bacteria?
paramyxovirus
MuSK protein
myasthenia gravis
fibrous dysplasia is commonly monostotic or polystotic?
monostotic
11/22 or 21/22 translocation?
Ewings syndrome
T or F mineral content is normal in osteoporosis?
True
1) Osteoporosis characterized by increased?
2) common fractures?
3) fractures lead to?
1) porosity of the skeleton resulting from reduced bone mass
2) Spine and femoral neck are prone for fractures
3) Loss of height and kyphoscoliosis
• Femoral neck fractures results in immobilization may lead to pulmonary embolism and pneumonia
Chronic osteomyelitis affects?
children! usually apical to mandibular first molar teeth, osteoblastic type
Paget’s Disease/ Osteitis
Deformans is characterized by frenzied?
osteoClastic activity followed by exuberant bone formation due to osteoblastic activity (he excess bone is architecturally abnormal and unstable)
Codmans triangle
Osteosarcoma
Eburnation
Smoothing of subchondral bone, polished
** osteoarthritis
Joint mice and osteophytes
Osteoarthritis
Crepitus
Cracking sound of bones
** osteoarthritis
Heberden nodes
Osteoarthritis
Small osteophytes on distal
GNAS gene
Fibrous dysplasia
Pagets is secondary cause of?
Osteosarcoma
