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Pathology 1 > Bone and Soft Tissue > Flashcards

Bone and Soft Tissue Flashcards

1
Q

Brittle bone disease?

A

Osteogenesis Imperfecta

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2
Q

1) Type 1 collagen?
2) type 2 collagen?
3) type 2 hypersensitivity?

A

1) Osteogenesis Imperfecta
2) osteoarthritis
3) myasthenia gravis

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3
Q

Treatment of osteoporosis?

A
  • Calcium and Vit D supplementation
  • Weight bearing exercise
  • Biphosphonates - decrease osteoclast-mediated bone resorption.
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4
Q

defective dentin in Osteogenesis Imperfecta is called?

A

dentinogenesis imperfecta

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5
Q

3 phases of development of Paget’s disease and fibrous dysplasia?

A

1) Osteoclastic: bone loss, hypervascularity
2) Osteoclastic and osteoblastic
3) Osteoblastic: formation of dense, mineralized bone

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6
Q

Most of Paget’s are monostotic or polyostotic?

A

polyostotic

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7
Q

1) 1 to 2.5 is?

2) below 1 is?

A

1) osteopenia

2) osteoporosis

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8
Q

Osteomyelitis casued by what bacteria?

A

Actinomycosis

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9
Q

New bone around dead bone is called?

A

involucrum

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10
Q

DEG stands for?

A

Drugs, Endocrine (thyroid), Gastric malnutrition (Vit D)

*** osteoporosis!

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11
Q

sequestra

A

dead bone

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12
Q

Paget’s has elevated _____ and normal levels of?

A

elevated serum alkaline phosphatase due to increased osteoblastic activity
•Serum calcium and phosphate are normal

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13
Q

What drugs inhibit osteoclast activity?

A

Prolia and bisphosphanate!

  • osteoclast has RankL
  • Osteoblast has RANK
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14
Q

APC gene

A

Gardners Syndrome

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15
Q

Osteogenesis Imperfecta

A
  • autosomal dominant
  • Brittle bone disease
  • Blue sclera, dentinogenesis imperfecta, hearing loss
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16
Q

Osteopetrosis

A
  • reduced osteoClast activity
  • defective REMODELING! Bone calcification ok
  • bone densitity or radioopaque
  • CN probs due to compression
17
Q

obliteration of bone marrow in osteopetrosis causes/

A
  • Reduced hematopoiesis
  • Recurrent infections
  • Normocytic anemia
18
Q

Osteoporosis is caused by?

**Idiopathic or secondary to?

A

menapuasal woman!
**Idiopathic or secondary to corticosteroids or multiple
myeloma

19
Q

onion

A

chronic osteomyelitits (children) OR ewing sarcoma

20
Q

F > M

A
  • giant cell tumor (brown’s tumor)
  • osteoporosis
  • myasthenia gravis
  • fibrous dysplasia
21
Q

Ewings syndrome mimics?

A

osteomyelitis

22
Q

Paget’s Disease/ Osteitis

Deformans is associated with what bacteria?

A

paramyxovirus

23
Q

MuSK protein

A

myasthenia gravis

24
Q

fibrous dysplasia is commonly monostotic or polystotic?

A

monostotic

25
Q

11/22 or 21/22 translocation?

A

Ewings syndrome

26
Q

T or F mineral content is normal in osteoporosis?

A

True

27
Q

1) Osteoporosis characterized by increased?
2) common fractures?
3) fractures lead to?

A

1) porosity of the skeleton resulting from reduced bone mass
2) Spine and femoral neck are prone for fractures
3) Loss of height and kyphoscoliosis
• Femoral neck fractures results in immobilization may lead to pulmonary embolism and pneumonia

28
Q

Chronic osteomyelitis affects?

A

children! usually apical to mandibular first molar teeth, osteoblastic type

29
Q

Paget’s Disease/ Osteitis

Deformans is characterized by frenzied?

A

osteoClastic activity followed by exuberant bone formation due to osteoblastic activity (he excess bone is architecturally abnormal and unstable)

30
Q

Codmans triangle

A

Osteosarcoma

31
Q

Eburnation

A

Smoothing of subchondral bone, polished

** osteoarthritis

32
Q

Joint mice and osteophytes

A

Osteoarthritis

33
Q

Crepitus

A

Cracking sound of bones

** osteoarthritis

34
Q

Heberden nodes

A

Osteoarthritis

Small osteophytes on distal

35
Q

GNAS gene

A

Fibrous dysplasia

36
Q

Pagets is secondary cause of?

A

Osteosarcoma

Pathology 1 (21 decks)

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