Blood Lecture 3 Flashcards
Blood type determined by
Presence/absence of specific antigens
Antigens
substances elicit immune response
Agglutinogen
Antigen that makes prod. of agglutinin
Agglutinins react with?
React with antigens if mixed incorrectly
Blood type determined how?
Which surface antigens present in RBC membranes
Type A blood will have which antibodies?
B
Rh+ RBC’s have?
Rh antigen
Rh- RBC’s lack?
Rh antigen
If Rh- receive Rh+ blood what happen
System makes anti Rh antibodies
If Rh- receive Rh+ second exposure what happens?
Agglutination and hemolysis
How anti-a or anti -b antibodies determined
Genetically
Transfusion is
transfer of whole blood or blood components
Where transfusion occurs
Into bloodstream or Red Bone Marrow
Transfusion used for
Anemia, blood volume, immunity
Incompatible blood transfusion causes
Agglutination
Universal recipient?
AB cause no antibodies
Universal donor?
Type O cause no antigens
Hemolytic newborn disease
If Rh- mother has Rh+ baby, mother might create anti Rh antibodies
What happens if mother creates anti-Rh antibodies
second pregnancy, antibodies cross placenta and cause agglutination
How blood typing determined
Drops of blood mixed in solution with antibodies, clumping occurs
Blood typing necessary for?
Avoid transfusion reactions
Anemia
Oxygen carrying capacity of blood reduced
Iron deficiency anemia
Inadequate absorption, or intake
Iron deficiency anemia who’s greatest risk
Women
Megaloblastic anemia due to
Inadequate b12 or folic acid
Megaloblastic anemia results in
abnormal RBC’s, ineffective oxygen transport
Pernicious anemia
Type of megaloblastic/unable to absorb b12
Hemorrhagic anemia
Excessive RBC loss
Acute blood loss
Increase in EPO levels
Chronic blood loss
Iron stores deplete, low hemoglobin
Hemolytic anemia
premature RBC plasma membrane rupture
Thalassemia
Deficient hemoglobin synthesis, RBC’s small/short lived
Thalassemia most common where
Mediterranean
Sickle cell disease
RBC changes shape and ruptures easily
Sickle cell disease general facts
Inherited, malaria belt
Aplastic Anemia
Destruction of Red bone marrow
Leukemia
Bone marrow cancer/ rapid WBC multiplication
Hemophilia
easily Bleed with minor traumas, clotting deficiency
Hemochromatosis
Body store and absorb too much iron
Jaundice
Excessive biliruben in blood, yellow discoloration