Blood Flow Flashcards

0
Q

Define velocity

A

The rate of movement of fluid particles along the tube

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1
Q

Define flow

A

Volume of fluid passing a given point per unit time

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2
Q

What is laminar flow?

A

Where there is a gradient of velocity from the middle to the edge of the vessel. Velocity is highest at the centre and stationary at the edge.

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3
Q

What is turbulent flow?

A

After a certain velocity, the velocity gradient breaks down and fluid tumbles over.

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4
Q

What effect does turbulent flow have on flow resistance?

A

Increased flow resistance

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5
Q

Define viscosity

A

The extent to which fluid layers resist sliding over one another.

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6
Q

Relationship between tube diameter and velocity?

A

At a constant gradient, the wider the tube, the faster the middle layers move, so mean velocity is proportional to the cross sectional area of the tube.

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7
Q

Relationship between mean velocity and viscosity?

A

Velocity is inversely proportional to the viscosity

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8
Q

Equation relating mean velocity, flow and cross-sectional area?

A

Flow = mean velocity x cross sectional area

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9
Q

Relationship between resistance and velocity?

A

As resistance increase, velocity increases (thicker the blood, harder it is to push around vessels - think of velocity gradient)

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10
Q

Relationship between cross sectional area and resistance?

A

As diameter increases, resistance decreases.

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11
Q

What is the effect of combining vessels in series on flow resistance?

A

The resistances add together

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12
Q

What is the relative pressure change in arteries, arterioles and capillaries

A

Arteries - pressure drop is small
Arterioles - pressure drop is large
Capillaries - pressure drop is small

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13
Q

Why is the pressure in arteries high when their resistance is low?

A

Resistance of arterioles

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14
Q

What is the effect in resistance and flow if the vessel wall stretches? Therefore what is the effect on increasing pressure on flow?

A

Resistance falls
Flow increases

As pressure increases, the easier it is for blood to flow through the vessel

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15
Q

How does distensibility of blood vessels produce capacitance?

A

As vessels widen, more blood transiently flows in than out.

16
Q

What is the systolic arterial pressure?

A

120mm Hg

17
Q

What is systolic arterial pressure affected by?

A

How hard the heart pumps
Total peripheral resistance
Compliance of arteries

18
Q

What is a typical diastolic pressure?

A

80 mm Hg

19
Q

What affects the diastolic pressure?

A

Systolic pressure

Total peripheral resistance

20
Q

What is the pulse pressure?

A

The difference between diastolic and systolic pressure

21
Q

What is a typical pulse pressure reading?

A

40 mm Hg

22
Q

How do you work out the average pressure?

A

Diastolic ➕ (1/3 ✖️ pulse pressure)

23
Q

Define total peripheral resistance

A

The sum of the resistance of all the peripheral vasculature in the systemic circulation.

24
Q

In the pulse wave, what is the dicrotic notch due to?

A

Pressure in the left ventricle falling below aortic pressure and subsequent backflow which closes the aortic value.

25
Q

What is the dicrotic wave due to?

A

This is the slight ride immediately following the notch. Slight increase in pressure is due to the recoil of blood off the aortic valve

26
Q

What is the role of arterioles as resistance vessels?

A

They control bloodflow to tissues by variable restriction

27
Q

Define vasoconstriction

A

Increase in tonic contraction of smooth muscle

28
Q

Define vasodilatation

A

Decrease in tonic contraction of smooth muscle

29
Q

Define vasomotor tone

A

The tonic contraction of smooth muscle

30
Q

What branch of the ANS mostly produces vasomotor tone and what antagonises it?

A

Sympathetic nervous system

Antagonised by vasodilator factors

31
Q

What are the vasodilator metabolites?

A

H+, K+ and adenosine

32
Q

What is the central venous pressure?

A

The pressure in the great veins supplying the heart

33
Q

What is venous return?

A

The rate of blood flow back to the heart

It limits cardiac output

34
Q

Equation for total peripheral resistance?

A

Blood pressure ➗ cardiac output