blood(cardiovascular system) Flashcards
Blood?
fluid that transports oxygen, nutrients, & hormones to cells & carries away carbon dioxide and other waste
what does blood assist with?
-Thermoregulation
-pH regulation
-osmoregulation
-immune system
what does blood consist of ?
-plasma (water + protein + other solutes
-formed elements (red&white blood cells, platelets
in the plasma…
-proteins help with transport molecules (albumin, alpha&beta globulins)
-help with immune response(gamma globulins)
-help with blood clot formation(fibrinogens)
Formed element?
-Erythrocytes(RBC) make up 99.9%
-Leucocytes(WBC)
-Platelets are fragments important for clotting
Hematocrit value?
hematocrit=formed element/whole blood
Erythrocytes(Red blood cell)
-mature cells lack nuclei and most other organelles since main purpose it to transport oxygen/gas
-Metabolism is anaerobic catabolism of glucose
-packed with protein called hemoglobin
hemoglobin?
- is 2 alpha and 2 beta subunits
-1 hemoglobin = 4 hemes
Hematopoiesis?
-process of making blood cells(occur in bone marrow)
-Through a process called erythropoiesis(only for RBC)
erythropoiesis ?
-process of making red blood cells
1)hemocytoblast (blood stem cell) differentiate into proerythroblast
2)Proerythroblast become erythroblasts
3)Erythroblasts matures into erythrocytes
Less than normal RBC Count?
anemia, will become hypoxemia(low blood oxygen, oxygen deprivation)
Too many RBCs?
-=Erythrocytosis(polycythemia)
-outcome=blood becomes too viscous, too much strain on heart&vessels, may lead to heart attack/stroke
-Kidney release glycoprotein hormone erythropoietin
ABO antigens?
-determine your blood type
-cross reaction will occur if donor is non-self blood type, leads to agglutination and cells are destroyed, called hemolysis
-ANTIBODIES WILL BIND TO FOREIGN SURFACE ANTIGENS
Rhesus(Rh) antigens ?
–determine your blood type
-surface antigen
-either Rh+ or Rh-
-exposure to Rh+ blood lead to development of antibodies
-The second exposure to Rh antigens would then lead to agglutination
Leukocytes
-WBC have nuclei and normal organelles
-two functions, defense against disease and recycling old/dead cells