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CLS > Blood Bank Lab Glossary > Flashcards

Blood Bank Lab Glossary Flashcards

1
Q

Absorption

A

Removal of an unwanted antibody

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2
Q

Adsorption

A

Providing antibody with corresponding antigen, antibody attaches to antigen, removes antibody from serum

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3
Q

Affinity

A

Bond between single antigen and combining site on antibody, a binding constant

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4
Q

Agglutination

A

Clumping of RBC’s or other particulate from interaction of antibody with corresponding antigen

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5
Q

Agglutinin

A

Antibody that agglutinates cells

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6
Q

Agglutinogen

A

Substance that stimulates production of agglutinin, acts as antigen

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7
Q

Allele

A

One of two or more genes that can occupy a specific locus on a chromosome

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8
Q

Allo-

A

Prefix indicating differences within a species (alloantibody = antibody from one individual against RBC’s of another)

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9
Q

Amorph

A

Gene that doesn’t produce detectable antigen, silent gene

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10
Q

Antenatal

A

Occurring before birth

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11
Q

Anti-A1 lectin

A

Anti-A1 serum produced from seeds of plants, reacts with A1 cells (Dolichos biflorus)

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12
Q

Anti-B lectin

A

Anti-B serum produced from seeds of plant, react with B cells (Bandeiraea simplicifolia)

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13
Q

Antibody Screen

A

Testing patient’s serum with group O reagent red cells to detect atypical antibodies

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14
Q

Anti-H lectin

A

Anti-H produced from seeds of plant (Ulex europaeus)

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15
Q

Antihuman globulin test (AGT)

A 
Check presence or absence of RBC's by immunoglobulin G and/or complement
Use xenoantibody (rabbit) to act as bridge between sensitized cells
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16
Q

Antihuman sera

A

Antibody produced in rabbits or other animal that is directed against human immunoglobulin and/or complement, can be polyspecific or monospecific

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17
Q

Antiserum

A

Reagent source of antibody, like commercial antiserum

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18
Q

Antithetical

A

Antigens that are product of allelic genes

19
Q

Autologous control

A

Testing patient’s serum with their own cells in effort to detect autoantibody activity

20
Q

Avidity

A

Strength with which a multivalent antibody binds to a multivalent antigen

21
Q

Biphasic

A

Reactivity occurring in two phases

22
Q

Chimera

A

Individual who possesses a mixed cell population

23
Q

Cis position

A

Location of two or more genes on the same on the chromosome of a homologous pair

24
Q

Codominant

A

Pair of genes in which neither is dominant over other, both are expressed

25
Q

Coomb’s serum

A

Antihuman serum

26
Q

Dosage

A

Phenomenon where antibody reacts more strongly with a RBC carrying a double dose (homozygous) than a RBC with single dose (heterozygous) of antigen

27
Q

Elution

A

Cells coated with antibody are treated so that Ag/Ab bonds disrupted, freed antibody collected and tested to identify its specificity

28
Q

Enzyme Treatment

A

RBC’s incubated with enzyme soltuion that cleaves some antigens and exposes others

29
Q

Ficin

A

Proteolytic enzyme from fig

30
Q

Genotype

A

Individual’s genetic makeup

31
Q

Hemolysin

A

Antibody that activates complement leading to cell lysis

32
Q

Heterozygous

A

Possessing different alleles at given locus

33
Q

Homozygous

A

Possessing a pair of identical alleles

34
Q

In vitro

A

Outside of body, in laboratory

35
Q

In vivo

A

Inside of living body

36
Q

Isogglutinins

A

Isoantibodies (anti-A, anti-B, anti-A,B) which are expected to be found in serum

37
Q

Lectin

A

Proteins present in plants which bind to carb determinant and agglutinate RBC’s through surface sugars

38
Q

Low ionic strength solution (LISS)

A

Reduces ionic strength of suspending medium which increases affinity of antigen for its corresponding antibody to increase sensitivity

39
Q

Major crossmatch

A

Compatability testing using recipient serum and donor RBC’s

40
Q

Minor crossmatch

A

Compatability testing using recipient RBC and donor serum

41
Q

Monoclonal

A

Antibody derived from single ancestral antibody-producing cell

42
Q

Phenotype

A

Outward expression of genes

On blood cells serologically demonstrable antigens constitute phenotype

43
Q

Prozone

A

Incomplete lattice formation caused by excess antibody compared to antigen, causes false negs

44
Q

Xeno-

A

Prefix indicating different species

CLS (15 decks)

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