Blood Flashcards
What is the basic arrangement of blood vessels?
Tunica Intima, Tunica Media and Tunica Adventitia
Describe Tunica Intima?
Single layer of squamous epithelial cells known as the endothelial cells supported by a basal lamina and a small layer of connective tissue
Describe Tunica Media?
Predominately muscle and can have a high amount of elastic tissue
Describe Tunica Adventitia?
Supporting connecting tissue
What are the largest arteries called?
Elastic arteries
What are the elastic fibres required for?
Elastic recoil
Describe the walls of elastic arteries?
Inner half of the wall obtains nutrients from the lumen and the outer half has its own blood supply called the vasa vasorum
What can been found between the tunica media and tunica adventitia?
External elastic membrane
Function of arterioles
Regulating blood flow in tissue
What are capillaries composed of?
Endothelial cells and basal lamina
What are pericytes?
Connective tissue cells that have contractile properties
What are the 3 forms of capillaries?
Continuous Capillaries
Fenestrated Capillaires
Discontinuous Capillaries
What is the function of the postcapillary venule?
Exchange of materials
What are the valves in the veins composed of?
Extensions of the tunica intima
Where are most proteins in the blood produced?
Liver
What is the role of Serum albumin?
Maintaining osmotic pressure
Why are mature red blood cells not true?
No nucleus or organelles
How long do erythrocytes last in circulation?
4 months
How are aged cells removed?
By spleen and liver
What are neutrophils?
Granulocytes and are the most common type of leukocytes
Describe the nucleus of the neutrophil?
Multilobed nucleus
What can neutrophils also be called?
Polymorphonuclear leukocyte
Where are eosinophils released from?
Bone marrow
How long do the eosinophils circulate for before moving into the tissue?
8-12 hours
Are eosinophils larger than neutrophils?
Yes
Describe the nucleus of the eosinophils?
Bilobed
What is the role of eosinophils?
Maintaining and inducing inflammation and fighting parasitic infections
Describe the nucleus in a basophil?
Bilobed
Role of the basophil?
Act as effector cells in allergic reactions
What do mast cells contain?
Herapin and histamine
Where are monocytes found?
Bone marrow and blood
What is monocytes together called?
Mononuclear phagocyte system
Describe the nucleus of the monocytes?
Non-lobulated
What are the 2 cases of lymphocyte?
B cells and T cells
Where does T cells differentiate?
Thymus
What do B cells give rise to?
Antibody secreting plasma cells
What do T cells do?
Form a complex set of cells that perform many defence functions
Function of Platelets?
Haemostasis
Do platlets have a nucleus?
No
What activates the production of fibrin which participates in clot formation
Platelets
What are the different types of stem cells?
Totipotent, Pluripotent, Multipotent and committed progenitor cells
What can form all types of cells of the adult, plus any extra embryonic tissue produced during development?
Totipotent
What can form all functional cell types of the animal?
Pluripotent
What can form a restricted set of cell types?
Multipotent
What can form only one cell type?
Committed Progenitor cells
Example of totipotent?
Fertilised ovum
Example of pluripotent?
Embryonic stem cells
Example of Multipotent?
Lymphoid stem cells
What is a Megakaryocyte?
Giant cells found in the bone marrow
What is plasma composed of?
Water, proteins, nutrients and salts
How can blood be separated?
Centrifuge
What is serum?
Fluid left after clotting factors have been removed from the blood
What are the proteins found in blood?
Serum albumin, clotting factors and complement components
What are erythrocytes?
Red blood cells
What is 1/3rd of the volume of RBC’s taken up by?
Haemoglobin
What is haemoglobin?
An iron-containing protein
What allows RBC’s to deform?
They contain a network of flexible cytoskeletal elements
What is the function of haemoglobin?
To pick up oxygen in the lungs and deliver it to the tissues of the body
What is a stack of red blood cells called and what can it indicate?
Rouleau and can indicate disease
What are the different types of white blood cells?
Neutrophils Lymphocytes Eosinophils Monocytes Basophils
What does the cytoplasm of neutrophils contain?
Granules
What cells are basophils similar to?
Mast cells
Where do B cells mature?
Bone marrow
What do platelets induce production of?
Fibrin
Sites of blood formation?
Embryonic - Liver and Spleen
After birth - Bone Marrow
Mature Skeleton - Vertebrae, Ribs and Skull
What happens to the marrow in bones not producing blood cells?
Becomes adipose tissue
What is the blood brain barrier induced by?
Astrocytes
What produces erythropoietin?
Kidney
What produces interleukins?
Leukocytes as well as other cells