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Biochemistry > BLock3: 8. atherosclerosis > Flashcards

BLock3: 8. atherosclerosis Flashcards

1
Q

what is atherosclerosis?
what percent of ppl with diabetes die of CVD?
3 components?
what is the clnical event/ consequence of atherosclerosis?

A
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2
Q

what are the stages of development of atherosclertoc plaque?
what is the very first step in pathology?
what is the effect of LDL infiltration on inflmmation in the artery?

A
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3
Q

why is atherosclerosis accelrated in diabetes?
discuss levels of ROS and NOS

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4
Q

describe dylipidemia in diabetes
what is increased?
what is decreased?

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5
Q

role of VLDL in proinflamation?

A
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6
Q

what are AGE?

A
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7
Q

concludign big picture things that relate to atherosclerosis? (4)

A

Insulin resistance and diabetes increase the risk for atherosclerosis

Major mechanisms involve:

-mitochondrial ROS formation

-Reduced NO production
-
-Changes in phenotype of endothelial cells, SMC and macrophages

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Biochemistry (16 decks)

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