BLock3: 4. phospholipids and sphingolipids Flashcards
- Describe the structural differences between the major classes of phospholipids
- glycerophospholipid vs sphingophospholipid
- how many carbons in glycerol
- geeneral structure o fa glycerophopholipid
how are phospholipids froemd from phosphatidic acid
site of synthesis?
what is the simplest phsophoglyceride?
how do you make phsopholipids?
- Describe the structure and explain the roles of specialized phospholipids
what is cardiolipin? describe structure
where is it found
function?
how is it related to apoptosis
what are ether phospholipids?
give an example of where one is found?
plateltetacitvating facotr?
what does it do?
surfactant? what phospholipid is in it?
made by what pneumocytes?
how do you diagnose possible respiratory distress syndrome?
Dipalmitoylphosphatidylcholine
- Explain the major synthesis pathways for different glycerophospholipids and discuss the physiologic importance of the “salvage” pathway
-what is CTP?
how is phosphatidic acid made?
must know this pathway to make phosphatidic acid so draw it.
how are triglycerides made?
how is phosphatidyl serine made
where is ps put after it is made?
how do you make phsophatidylcholine?
what does it depend on?
what is the salvage pathway?
sources of choline?
how is this different than making phosphatidylcholine from dietary precursor?
- Describe the degradation pathways for phospholipids and explain the differences in various phospholipases
A1
A2
C
D
which is a major mech for cytotoxicity of snake and bee venoms?
many different types of phopholipase A2 enzymes:
-cytosolic?
cytosolic is activated by?
-intracllular?
secretory?
pancreatic
- Describe the generic structure, synthesis, degradation and roles of sphingolipids
structure?
most common FA used in sphingomyelin?
roles in body?
how does it interact with cholesterol?
how is sphingomyelin degraded?
neimann pick type 1 disease?
s/s?
sphingolipid vs glycolipid?
ganglioside?
cerebroside?
