Black Box Warnings: Antimicrobials/ Infection

Question 1

Associated with disabling and potentially irreversible serious adverse reactions including tendonitis & tendon rupture; peripheral neuropathy; CNS effects; exacerbation on muscle weakness in patients with myasthenia gravis.

Answer 1

Fluoroquinolones

Question 2

• Nephrotoxicity, increased risk in those with impaired renal function and in those who receive high dosage of prolonged therapy.
• Ototoxicity, usually irreversible.
• Neurotoxicity manifested by numbness, skin tingling, muscle twitching and convulsions.
• Fetal harm when administered to pregnant women.

Answer 2

Aminoglycosides

Question 3

Do not use to treat noninvasive forms of fungal disease in patients with normal neutrophil counts (neutrophils are a type of white blood cells)

Answer 3

Polyenes