BIPOLAR DISORDERS AND ANTIMANIC AGENTS Flashcards

1
Q

Bipolar I
Bipolar II
Cyclothymic Disorder

A
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2
Q

Bipolar I Diagnostic Criteria

At least ? Manic Episode

A

1

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3
Q

Major depressive episodes are common in
bipolar I disorder but are ? for the diagnosis of bipolar I disorder.

A

not required

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4
Q

Bipolar I Diagnostic Criteria

Elevated, expansive, or irritable mood and
increased activity/energy for at least ? week

A

1

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5
Q

Diagnostic Criteria for Mania
Marked ? in functioning

A

impairment

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6
Q

Marked impairment in functioning

A

Diagnostic Criteria for Mania

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7
Q

Mania Symptoms mnemonic

A

DIGFAST

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8
Q

DIGFAST

A

Mania Symptoms mnemonic

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9
Q

Mania Symptoms mnemonic
DIGFAST

D

A

Distractibility up

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10
Q

Mania Symptoms mnemonic
DIGFAST

I

A

Irresponsibility

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11
Q

Mania Symptoms mnemonic
DIGFAST

G

A

Grandiosity

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12
Q

an exaggerated sense of one’s importance, power, knowledge, or identity

I am going to be the next big thing to every exist.

A

Grandiosity

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13
Q

Mania Symptoms mnemonic
DIGFAST

F

A

Flight of Ideas

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14
Q

Mania Symptoms mnemonic
DIGFAST

A

A

Activity increases up

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15
Q

Mania Symptoms mnemonic
DIGFAST

S

A

Sleep decreases

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16
Q

Mania Symptoms mnemonic
DIGFAST

T

A

Talkativeness up

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17
Q

Which only requires only one mania eposide

Bipolar I
Bipolar II
Cyclothymic Disorder

A

Bipolar I

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18
Q

At least one hypomanic episode + a major depressive episode (required)

Bipolar I
Bipolar II
Cyclothymic Disorder

A

Bipolar II

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19
Q

Bipolar II
At least ? hypomanic episode +
a ? episode (required)

A

one

major depressive

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20
Q

Hypomania: Elevated, expansive,
or irritable mood and increased
activity/energy for at least 4 days

Bipolar I
Bipolar II
Cyclothymic Disorder

A

Bipolar II

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21
Q

Bipolar II

Hypomania: Elevated, expansive,
or irritable mood and increased
activity/energy for at least ? days

A

4

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22
Q

What is a lesser version of Mania

A

Hypomania

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23
Q

What a more heighted version of hypomania

A

Mania

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24
Q

Maniac for 7 days without major depression

Bipolar I
Bipolar II
Cyclothymic Disorder

A

Bipolar I

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25
Q

Hypomaia for 4 days with major depression

Bipolar I
Bipolar II
Cyclothymic Disorder

A

Bipolar II

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26
Q

Diagnostic Criteria for Mania

Is ? or more symptooms of mania

A

three

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27
Q

Chronic fluctuating mood
* For at least 2 years, for at least 50% of the time, here have been multiple

Bipolar I
Bipolar II
Cyclothymic Disorder

A

Cyclothymic Disorder

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28
Q

Hypomanic and Depressive episodes without meeting full criteria

Bipolar I
Bipolar II
Cyclothymic Disorder

A

Cyclothymic Disorder

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29
Q

Cyclothymic Disorder

Chronic fluctuating mood
* For at least ? , for at least 50% of the time, there have been multiple:

A

2 years

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30
Q

What is the main(First) drug to treat Bipolar Disorders

A

Lithium

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31
Q

What Is Lithium

A

Mood Stablizer

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32
Q

First drug by the FDA to be used for Bipolar Disorder?

A

Lithium

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33
Q

Avoid alcohol and other CNS depressant drugs

A

Lithium

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34
Q

Lithium Drug interactions

A

ACE Inhibitors(pril)
Diuretics(depltes water and sodium from body)
TCA - antihistimine/anticholergic drugs
Nsaids

35
Q

Lithium
? [Na] –> ? [Li]

A

Decreased
Increased

36
Q

Lithium

Dehydration can ? serum concentration

A

increase

37
Q

Lithium

serum level of ? to ? mEq/L

A

0.6 to 1.2 mEq/L

38
Q

Lithium

Monitor at least ? days after dose changes

A

5

39
Q

Lithium

Every ? months while in maintenance

A

1-3

40
Q

Lithium

What are the labs you check

A

Lithium Levels, BUN, Creatine (Kidneys)

41
Q

Lithium

Thyroid must be assessed ? !

A

annually

42
Q

Goiter

A

Thyroid related-

43
Q

Lithium

Less than 1.5

A

Common Adverse Reactions

44
Q

Lithium

1.5 to 2.0

A

Early Indication

45
Q

Lithium

2.0 to 2.5

A

Advance Indication

46
Q

Lithium

> 2.5

A

Severe Toxicity

47
Q

Diarrhea, Nausea, Vomiting, Thirst, Polyuria, Muscle Weakness, Fine Hand Tremors, Slurred Speech and Lethargy

A

Lithium Common Adverse Effects

48
Q

Fine hand Tremors

A

Lithium Common Adverse Effects

49
Q

Confusion, Sedation, Poor Coordination, Coarse Tremors, Cont GI Distress N/V/D

A

Lithium Early Indications

50
Q

Coarse Tremors

A

Lithium Early Indications

51
Q

Extreme Polyuria, Tinnitus, Giddiness, Jerking Movement , Blurred Vision, Ataxia, Seizure, Sev Hypotension, Coma , Death from RR

A

Lithium Advanced Indications

52
Q

Jerking Movement

A

Lithium Advanced Indications

53
Q

Rapid condition to death or coma

A

Lithium Severe Toxicity

54
Q

Hemodialysis

A

Lithium Severe Toxicity

55
Q

Lithium Mnemonic

A

Lithium

56
Q

Lithium Mnemonic

L

A

Levels (0.6-1.2 mEq/L)

57
Q

Lithium Mnemonic

I

A

Increased urination (polyuria)/ Insipidus

58
Q

a rare condition where you pee a lot and often feel thirsty

A

Insipidus

59
Q

Lithium Mnemonic

T

A

Tremors/Thirst

60
Q

Lithium Mnemonic

H

A

Hypothyroidism

61
Q

Lithium Mnemonic

I2

A

INTERACTIONS
ACE Inhibitors(pril)
Diuretics(depltes water and sodium from body)
TCA - antihistimine/anticholergic drugs
Nsaids

62
Q

Lithium Mnemonic

U

A

Upset stomach

63
Q

Lithium Mnemonic

M

A

Muscle weakness/ Miscellaneous- EKG
changes)

64
Q

What has Blurred vision, nystagmus and diplopia N/V Hedaches. as side effect

A

Valproic acid
Lithium
Carbamazepine
LAMOTRIGINE

65
Q

What does Valproic acid, Lithium, Carbamazepine, LAMOTRIGINE have in common

A

Vision Distrubance
Burred vision, nystagmus and diplopia N/V Headaches

66
Q

Black Box: Hepatotoxicty + Pancreatitis + Teratogenic

A

Valproic acid

67
Q

Valproic acid

Monitor ? + ? periodically

A

Monitor LFTs + amylase periodically

68
Q

Jaundice

A

Valproic acid

69
Q

Rarely Thrombocytopenia

A

Valproic acid

70
Q

Which put more at risk of bruising

A

Valproic acid

71
Q

Used after Lithuim fails

A

CARBAMAZEPINe

72
Q

?
Stevens-Johnson syndrome, bone marrow
suppression leading to anemia and agranulocytosis

A

CARBAMAZEPINe

73
Q

Black box: Stevens-Johnson syndrome

A

LAMOTRIGINE
Carbamazepine

74
Q

Black box: Stevens-Johnson syndrome symptoms 3

A

Fever, Rash, Mouth sores

75
Q

All The mediation on this test will have CNS isConcerns to avoud driving and Operating Heavy Machinery right

A

Yes

76
Q

CNS Effects

A

Visual Distrubance, and Dizzieness, drowiness, Headaches,

Catiuon while driving

77
Q

Carbamazepine

Check ?

A

BMP (Na, BUN)

78
Q

Carbamazepine

What disease state should we be cautious with? 3

A

Kidney, Heart Failure, autoimmune disease.

79
Q

Carbamazepine

Administration
Give ? food (can cause GI symptoms)
Can give at ?, if possible, to sleep through symptoms

A

With

bedtime

80
Q

Carbamazepine

Due to ?
* Periodic checks of ?
* Report ?

A

bone marrow suppression
CBC
fever/sore throught

81
Q

Due to bone marrow suppression

A

Carbamazepine

82
Q

When Stevens-Johnson Syndrome (SJS) Appears what should you do

A

Stop Medication.

83
Q

Slow titration regimen

A

LAMOTRIGINE

84
Q
A