Biological Flashcards
What is Cell body
- Main part of cell, contains nucleus and mitochondria.
What is the Nucleus
- The nucleus-Houses genetic material for cell
What is the Mitochondria
- The mitochondria- Site of aerobic respiration where energy is released from glucose. Provides cells with energy.
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What is dendrites?
branches at top end of neuron, attached to cell body and receives messages from other neurons to trigger action potential (Electrical impulse) within cell.
What is the axon?
- The axon long, branch extension of cell body, passes electrical impulse down to end of neuron to allow communication with other neurons.
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What is the axon hillock
triggers nerve impulse and connects cell body to axon
What is the Myelin Sheath?
Fatty deposit that surrounds and electrically insulates axon to help speed up message transmission rate and allows for electrical nerve impulses to be passed along. Insulates (Keeps in impulses)
What is Nodes of Ranvier?
breaks between cells along adjacent myelin sheath.
What is the Axon terminal?
Axon terminals are at end of axon, at end of these are terminal buttons/boutons. Axon terminals pass nerve impulses from cell body to parts of the body they control/activate (Muscle, gland, Another neuron.)
What are terminal buttons/boutons?
Very end of neuron where nerve impulse becomes a chemical message that can be passed to dendrite of another neuron.
What are vesicles?
Tiny sacs that contain molecules of neurotransmitter chemicals.
What are Neurotransmitters?
Chemicals that passes messages between neurons.
What is action potential?
Action Potential-
-Beginning of one cell communicating with another, leads to synaptic transmission.
-Actual method by which nerve impulse travels down axon of neuron to stimulate release of neurotransmitters, tiny electrical impulse triggered by change of neuron’s electrical potential.
Neurons have resting membrane potential of about -70mV meaning that inside of neuron has slight negative charge in relation to outside. When neuron receives message from another neuron, this chemical message can either stimulate an Excitatory Postsynaptic Potential (Reduced charge by depolarisation), Sodium channels (S-) open in response to stimulus and can generate transmission along axon or Inhibitory Postsynaptic Potential (Increased charge by hyperpolarisation) opening of Potassium (K+ Channels) due to stimulus
More excitatory than inhibitory means that action potential will occur.
What is synaptic transmission?
Synaptic transmission
when the action potential reaches axon terminal (From axon Hillock), calcium channels will obey, flooding terminal buttons with calcium ions. Vesicles containing neurotransmitter substance released, travels down to outer membrane of terminal button where vesicle casing will fuse with membrane and allow for neurotransmitter to be released from vesicle into synaptic cleft.
Receptors on postsynaptic neuron designed to bind to specific neurotransmitter and when detected, the neurotransmitter molecule will then be absorbed by postsynaptic neuron. Any neurotransmitter molecules not absorbed by receptors of postsynaptic neuron then will either diffuse away (be destroyed), or neurotransmitters will be absorbed again by presynaptic neuron (Reuptake) and they are recycled, ready to be fired again. Reabsorbed molecules will be destroyed by enzymes within neuron to “Turn off” neuron in preparation for future action potential.
What are recreational drugs?
They alter brain function which results in changes of mood, perception and conscious experience
For this reason they are called psychoactive drugs
Why do recreational drugs lead to becoming addicted?
Recreational drugs change function of neurotransmitters is brain, by preventing enzymes from breaking down dopamine neurotransmitter, leading to more dopamine being in synaptic cleft and going through reuptake via pre-synaptic neuron, this causes intense feeling of euphoria while dopamine remains. The body responds by down-regulating (reducing) the amount of dopamine naturally in body, and so eventually, when drug has worn off, less dopamine in brain then there was before.
natural activities make a smoother curve, dopamine level increases and decreases at lower difference
With drugs, spiking occurs (Euphoria), down-regulation of dopamine leads to severe drop of dopamine levels (Dysphoria)
Therefore, person becomes dependent on drug to take away negative feelings, (Dysphoria) and they also become tolerant (Meaning that more of the drug is needed to cause same feeling), leads to addiction
What is the historical context of the brain?
There is evidence that shows some basic brain function was understood early in, fossil evidence shows that trepanning (Drilling hole into skull to treat problems on brain surface) was done in connection with migraines and brain functioning. Hippocrates, (Greek) put forward idea that each side/hemisphere of our brain served a distinct function. In 19th century, phrenology (Mapping bumps on person’s skull and using these to deduce aspects of person’s character) was introduced by Franz Joseph Gall.
Phineas Gage, railway worker in 1848 USA, iron rod in head, the iron entered through Gage’s cheek, passed through his brain, and shot out of the top of his head and through frontal lobe., for remaining 11 years of life, he went from being reliable and civil, calm to irresponsible, violent, unsociable, aggressive, irreverent (disrespectful),personality changed “fitful, irreverent, indulging at times in the grossest profanity (which was not previously his custom), manifesting but little deference for his fellows, impatient of restraint or advice when it conflicts with his desires - John Harlow (1868)”. Phineas Gage’s memory wasn’t affected as memory is in temporal lobe. Prefrontal cortex/lobe damage (Brain area just behind forehead) was to be blamed for personality change.
Series of case studies like Phineas allowed for brain to be mapped by physicians. Paul Broca, neuroscientist, and physician treated stroke patients in 19th century. His most famous case study was that of a patient known as ‘Tan’, who lost ability to say words other than tan, through post-mortem examination, lower part of left frontal lobe damage was found, now known as Broca’s area, is responsible for motor control in speech production, damage to this area causes difficulty replying to speech
Wernicke’s area, named after Carl Wernicke, 19th century German neurologist, situated at rear of left of temporal lobe as it joins parietal lobe, involved with speech understanding. Patients with Wernicke’s aphasia (disturbance of language production/comprehension due to brain dysfunction/damage) produce meaningless speech.
Scientists have built functional map of brain using research, case studies, neuroimaging techniques, no longer rely on lesion studies (Investigating effect of specific brain area on behaviour)
How is brain trauma linked to aggressive behaviour?
Case of Phineas Gage demonstrated that damage to frontal lobes in the brain may have caused him to show an increase in aggressive behaviour which suggests a possible biological basis for aggression.
Frontal lobe damage may serve as biological basis for aggression.
Experiments conducted on cats, rodents and investigated biological structure of brain that underlies aggression.
Hypothalamus damage affects aggression.
Studies show three different, specific types of behaviour:
Offensive behaviour- Physically attacking another animal, intention to harm. Medial Hypothalamus damage
Defensive behaviour- Shown in response to attack threat. Dorsal hypothalamus damage
Predatory aggression- Attacking other species to gain food. Lateral Hypothalamus damage
Lesions/ damage to different areas of the brain has been shown to activate behaviour associated specifically with one type of aggression.
How does midbrain affect aggression?
Midbrain-Contains an area called periaqueductal grey matter (PAG, area of grey matter within midbrain which plays a role in pain modulation and defensive behaviour) which links amygdala and hypothalamus with prefrontal cortex (Seen before in Phineas Gage). Has a role in co-ordinating and integrating behavioural responses to perceived internal and external stressors such as pain and threat , can be images, and sounds also (Detecting whether something is threatening). Regulating pain and external behaviour. Responses are co-ordinated in prefrontal cortex. Lesions to PAG in rats that have recently given birth (Protective) show increase in aggression when rats confronted with potential threat i.e. unfamiliar male rats (who may kill babies who are not there’s) in cage (Lonstein and Stern 1998).
How does amygdala affect aggression?
Amygdala- linked to PAG, Centre for Emotions, emotional behaviour, motivation. Integrates internal and external stimuli, and every sensory modality has input, which when combined gives us an instinctive feeling/reaction to environment that will include aggression. Prefrontal cortex also connects to amygdala and may lead to expression of aggression. Prefrontal cortex weighs out pros and cons of expressing aggression.
How does hypothalamus affect aggression?
Hypothalamus-Maintains homeostasis (Response which maintains human body in reaction to change in external conditions) through hormone regulation (Including sexual function), linked to aggressive behaviour in males via testosterone production.
How does prefrontal cortex affect aggression?
Prefrontal cortex-Sits right behind forehead, at front of forehead governs behavioural regulation and social interaction (Is this acceptable, how am I going to look?) , delays gratification (Want for satisfaction), impulse control and has connections to amygdala and hypothalamus, damage normally results in problems with anger management, irritability, impulse control.
Evaluating using animals for brain trauma research
Advantages
· Prevents unethical research with humans being conducted
· Animals such as rats bred for testing and so are easily/readily available
· Researchers are now required to conduct cost-benefit analysis to ensure what they are using animals for is justified and necessary as ethical issues as damaging animals brain (Lesion), are included and are harmful. Is benefit of research outweighing harm to animal.
· Some basic brain structures are similar across species so animal research is useful; for understanding aggression human aggression
Disadvantages
· Difficult to generalise results of small animals brain structure in association with aggression as , even though brain structures in animals are similar, the human brain is more complex
· Difficulty with generalisations across species to humans as our brains and emotions are much more complex than animals
· Some researchers argue that there are some basic similarities and so there is generalisability but to a limited extent
· Some argue that the use of animals is immoral
Evaluate Brain structure effect on aggression
upport for the link between brain function/structure and aggression comes from human case studies i.e Phineas Gage whose social behaviour was largely affected by prefrontal cortex damage, from calm, well-mannered, social, to aggressive, irritable, and using profanity
2. However, he’s a single case and unique, so effects of brain damage may not represent all humans (Idiographic- Focuses on specific person), although other case studies also support involvement of prefrontal cortex and relation to aggressive behaviour (Adds credibility)
3. More specific support comes from Raine et al (1997) who used a sample of 41 murderers and found lower prefrontal cortex activity in PET scans
4. Raine conducted research on Prisoners from New Mexico, and found that they had smaller amygdala (Responsible for emotions and emotional responses)
5. Biological approach to explain aggression supports genetic basis because our genetic information determines are brain structure, therefore males are predisposed to be more aggression compared to females.