Biological Flashcards
What is Cell body
- Main part of cell, contains nucleus and mitochondria.
What is the Nucleus
- The nucleus-Houses genetic material for cell
What is the Mitochondria
- The mitochondria- Site of aerobic respiration where energy is released from glucose. Provides cells with energy.
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What is dendrites?
branches at top end of neuron, attached to cell body and receives messages from other neurons to trigger action potential (Electrical impulse) within cell.
What is the axon?
- The axon long, branch extension of cell body, passes electrical impulse down to end of neuron to allow communication with other neurons.
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What is the axon hillock
triggers nerve impulse and connects cell body to axon
What is the Myelin Sheath?
Fatty deposit that surrounds and electrically insulates axon to help speed up message transmission rate and allows for electrical nerve impulses to be passed along. Insulates (Keeps in impulses)
What is Nodes of Ranvier?
breaks between cells along adjacent myelin sheath.
What is the Axon terminal?
Axon terminals are at end of axon, at end of these are terminal buttons/boutons. Axon terminals pass nerve impulses from cell body to parts of the body they control/activate (Muscle, gland, Another neuron.)
What are terminal buttons/boutons?
Very end of neuron where nerve impulse becomes a chemical message that can be passed to dendrite of another neuron.
What are vesicles?
Tiny sacs that contain molecules of neurotransmitter chemicals.
What are Neurotransmitters?
Chemicals that passes messages between neurons.
What is action potential?
Action Potential-
-Beginning of one cell communicating with another, leads to synaptic transmission.
-Actual method by which nerve impulse travels down axon of neuron to stimulate release of neurotransmitters, tiny electrical impulse triggered by change of neuron’s electrical potential.
Neurons have resting membrane potential of about -70mV meaning that inside of neuron has slight negative charge in relation to outside. When neuron receives message from another neuron, this chemical message can either stimulate an Excitatory Postsynaptic Potential (Reduced charge by depolarisation), Sodium channels (S-) open in response to stimulus and can generate transmission along axon or Inhibitory Postsynaptic Potential (Increased charge by hyperpolarisation) opening of Potassium (K+ Channels) due to stimulus
More excitatory than inhibitory means that action potential will occur.
What is synaptic transmission?
Synaptic transmission
when the action potential reaches axon terminal (From axon Hillock), calcium channels will obey, flooding terminal buttons with calcium ions. Vesicles containing neurotransmitter substance released, travels down to outer membrane of terminal button where vesicle casing will fuse with membrane and allow for neurotransmitter to be released from vesicle into synaptic cleft.
Receptors on postsynaptic neuron designed to bind to specific neurotransmitter and when detected, the neurotransmitter molecule will then be absorbed by postsynaptic neuron. Any neurotransmitter molecules not absorbed by receptors of postsynaptic neuron then will either diffuse away (be destroyed), or neurotransmitters will be absorbed again by presynaptic neuron (Reuptake) and they are recycled, ready to be fired again. Reabsorbed molecules will be destroyed by enzymes within neuron to “Turn off” neuron in preparation for future action potential.
What are recreational drugs?
They alter brain function which results in changes of mood, perception and conscious experience
For this reason they are called psychoactive drugs
Why do recreational drugs lead to becoming addicted?
Recreational drugs change function of neurotransmitters is brain, by preventing enzymes from breaking down dopamine neurotransmitter, leading to more dopamine being in synaptic cleft and going through reuptake via pre-synaptic neuron, this causes intense feeling of euphoria while dopamine remains. The body responds by down-regulating (reducing) the amount of dopamine naturally in body, and so eventually, when drug has worn off, less dopamine in brain then there was before.
natural activities make a smoother curve, dopamine level increases and decreases at lower difference
With drugs, spiking occurs (Euphoria), down-regulation of dopamine leads to severe drop of dopamine levels (Dysphoria)
Therefore, person becomes dependent on drug to take away negative feelings, (Dysphoria) and they also become tolerant (Meaning that more of the drug is needed to cause same feeling), leads to addiction
What is the historical context of the brain?
There is evidence that shows some basic brain function was understood early in, fossil evidence shows that trepanning (Drilling hole into skull to treat problems on brain surface) was done in connection with migraines and brain functioning. Hippocrates, (Greek) put forward idea that each side/hemisphere of our brain served a distinct function. In 19th century, phrenology (Mapping bumps on person’s skull and using these to deduce aspects of person’s character) was introduced by Franz Joseph Gall.
Phineas Gage, railway worker in 1848 USA, iron rod in head, the iron entered through Gage’s cheek, passed through his brain, and shot out of the top of his head and through frontal lobe., for remaining 11 years of life, he went from being reliable and civil, calm to irresponsible, violent, unsociable, aggressive, irreverent (disrespectful),personality changed “fitful, irreverent, indulging at times in the grossest profanity (which was not previously his custom), manifesting but little deference for his fellows, impatient of restraint or advice when it conflicts with his desires - John Harlow (1868)”. Phineas Gage’s memory wasn’t affected as memory is in temporal lobe. Prefrontal cortex/lobe damage (Brain area just behind forehead) was to be blamed for personality change.
Series of case studies like Phineas allowed for brain to be mapped by physicians. Paul Broca, neuroscientist, and physician treated stroke patients in 19th century. His most famous case study was that of a patient known as ‘Tan’, who lost ability to say words other than tan, through post-mortem examination, lower part of left frontal lobe damage was found, now known as Broca’s area, is responsible for motor control in speech production, damage to this area causes difficulty replying to speech
Wernicke’s area, named after Carl Wernicke, 19th century German neurologist, situated at rear of left of temporal lobe as it joins parietal lobe, involved with speech understanding. Patients with Wernicke’s aphasia (disturbance of language production/comprehension due to brain dysfunction/damage) produce meaningless speech.
Scientists have built functional map of brain using research, case studies, neuroimaging techniques, no longer rely on lesion studies (Investigating effect of specific brain area on behaviour)
How is brain trauma linked to aggressive behaviour?
Case of Phineas Gage demonstrated that damage to frontal lobes in the brain may have caused him to show an increase in aggressive behaviour which suggests a possible biological basis for aggression.
Frontal lobe damage may serve as biological basis for aggression.
Experiments conducted on cats, rodents and investigated biological structure of brain that underlies aggression.
Hypothalamus damage affects aggression.
Studies show three different, specific types of behaviour:
Offensive behaviour- Physically attacking another animal, intention to harm. Medial Hypothalamus damage
Defensive behaviour- Shown in response to attack threat. Dorsal hypothalamus damage
Predatory aggression- Attacking other species to gain food. Lateral Hypothalamus damage
Lesions/ damage to different areas of the brain has been shown to activate behaviour associated specifically with one type of aggression.