Biochem

Question 1

alpha-1,6-glucosidase

Answer 1

• glycogen debranching enzyme
• implicated in cori disease
• less severe than mcArdle disease, rare cramping etc

Question 2

glucose 6 phosphatase

Answer 2

• glycogen breakdown
• disorder leads to glycogen storage disorder (McArdle)
• severe cramping, myoglobinuria

Question 3

3-hydroxy-3methylglutaryl co-enzyme A synthase

Answer 3

• HMG CoA, rate limiting step in cholesterol synthesis

- inhibited by statins

Question 4

michaelis-menten constant

Answer 4

• Km

- substrate concentration when reaction is at 1/2 Vmax