Benzodiazepines

Question 1

MOA:

Answer 1

Bind to GABA and allow Chloride ions to pass through to -> hyperpolarizarion -> no generation of AP

Question 2

Diazepam and midazolam (uses, doses, routes of A)

Answer 2

Diazepam - 5-20mg - premeditation, sedation - oral, IV

Midazolam - IV, IM - 1-5mg - premeditation, sedation

Question 3

Propofol and etomidate ( initial dose, duration, time of onset, repeat dose)

Answer 3

Propofol - 40S - 1mg/kg - 3-5mins @ 0.5mg/kg

Etomidate- <1min - 0.1mg/kg - 3-5 mins 0.05mg/kg