Basic CNS Pharmacology & CNS Stimulants Flashcards

1
Q

Which part of the brain functions in sensations, perception, voluntary movement, learning, speech, and cognition?

A

Cerebral cortex - processes and interprets information

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2
Q

Which part of the brain functions in respiration, cardiac and vasomotor control, and reticular formation?

A

Medulla of the hindbrain

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3
Q

Which part of the brain functions in voluntary movement in space and time, controls balance and eye movements, as well as repetitive cognitive functions?

A

Cerebellum

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4
Q

Which part of the brain acts as a relay center and filters and modulates sensory information transmission to the cerebral cortex?

A

Thalamus

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5
Q

Which part of the brain controls the ANS, hormonal regulation, internal homeostasis, and emotions?

A

Hypothalamus

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6
Q

Which part of the forebrain acts in voluntary motor control?

A

Basal ganglia

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7
Q

Which part of the brain contains the cingulate gyrus, hippocampal formation, and amygdala?

A

Limbic system

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8
Q

What are 3 functions of the limbic system?

A

Emotions, social behavior, and memory

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9
Q

What are the 4 steps in neurotransmitter release?

A
  1. Neurotransmitter synthesis
  2. Vesicular storage
  3. Enzymatic breakdown of non-vesicular neurotransmitter
  4. Exocytosis
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10
Q

What are the 3 steps in neurotransmitter action?

A
  1. Auto-receptor feedback inhibition
  2. Post-synaptic receptor activation
  3. Deactivation by enzymatic breakdown
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11
Q

Neurotransmitters are chemical messengers that bind where?

A

To receptor molecules present on the surfaces of adjacent neurons

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12
Q

Where are neuromodulators produced?

A

Neurons

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13
Q

Neuromodulators are chemical messengers produced by neurons that act in a ____ manner.

A

Paracrine

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14
Q

Neurohormones are chemical messengers that act as what?

A

True hormones

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15
Q

Where are neurohormones produced?

A

Neurons

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16
Q

What is an analeptic?

A

CNS stimulants, producing an arousal effect characterized by return of consciousness in anesthetized or sedated patients

17
Q

What type of analeptic is Doxapram?

A

Respiratory analeptic

18
Q

What are 2 common uses of Doxapram?

A
  1. Arousal from anesthetic overdose

2. Diagnosis of laryngeal paralysis

19
Q

When is the use of Doxapram contraindicated?

A

In animals susceptible to seizures

20
Q

What are Methylxanthines?

A

Bronchodilators

21
Q

Name 1 of the 3 Methylxanthines.

A
  1. Caffeine
  2. Theophylline
  3. Theobromine
22
Q

There are 4 pharmacological actions of Methylxanthines. What are 2 of those?

A
  1. CNS stimulant
  2. Mild diuretic
  3. Smooth muscle relaxant
  4. Respiratory muscle stimulant
23
Q

What are the 2 targets for Methylxanthines?

A
  1. Phosphodiesterase

2. Adenosine receptor

24
Q

Inhibition of phosphodiesterase leads to what?

A

Accumulation of cyclic 3’, 5’ AMP

25
Q

There are 4 side effects associated with Methylxanthines. What are 2 of those?

A
  1. CNS excitement/restlessness
  2. Seizures
  3. GI disturbance (nausea and vomiting)
  4. Cardiac dysrhythmia