Basal ganglia

Question 1

Basal ganglia function

Answer 1

Motor control and learning, behaviour and learning

It integrates motor and sensory information from the cortex

Question 2

Parkinson’s disease

Answer 2

Associated with tremor in the basal ganglia
It s a hypo-kinetic disease 
Progressive disease
Akinesia-Difficulty with movement
Leads to dementia

Question 2

Parkinson’s disease

Answer 2

Associated with tremor in the basal ganglia
It s a hypo-kinetic disease 
Progressive disease
Akinesia-Difficulty with movement
Leads to dementia

Question 3

What does Parkinson’s do in therms of neurotransmitters

Answer 3

Specific loss of dopamine cell which produce dopamine

without dopamine no movement can occur

Question 4

Treatment for Parkinson’s

Answer 4

MPTP gives dopamine

Question 5

substantia nigra

Answer 5

the substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.

Question 6

Disinhibition

Answer 6

Inhibitory cells being inhibited by another inhibitory cell causes excitation happens in the cortex

Question 7

2 pathways to dopaminergic modulation

Answer 7

Direct pathway-From cerebral cortex to SN

Indirect pathway- GPe and STN is needed to be in balance for signal to be passed to SN

Question 8

Basal ganglia dysfunction terms

Answer 8

Hypo-kinetic- little movement
Hyper-kinetic- Too much movement
Motor dysfunction occurs through imbalance of pathways

Question 9

Neuronal synchronisation in BG

Answer 9

rate and pattern of neuronal firing code for BG