bailey gram negative lecture 1

Question 1

cleaves linkages between N-acetylnuramic acid and N-acetylglucosamine

Answer 1

lysozyme (aka muramidase)

Question 2

bacteriostatic effects via sequestering iron

Answer 2

lactoferrin

Question 3

disrupts bacterial membranes of gram negative and gram positive (as well as fungi)

Answer 3

cathelicidin

Question 4

create pores in microbes (all microbes can be effected)

Answer 4

defensins

Question 5

alpha-defensins produced by ____ and _____

Answer 5

neutrophils; paneth cells (in intestine)

Question 6

beta-defensins produced by _____

Answer 6

epithelial cells

Question 7

lysozyme (aka muramidase) cleaves _____ between N-acetylnuramic acid and N-acetylglucosamine

Answer 7

beta 1,4 glycosidic linkages

Question 8

how do pathogenic bacteria overcome innate barrier defenses?

Answer 8

1. acid resistance
2. fimbriae/pili
3. bacterial structures

Question 9

microbes with low ____ tend to be acid resistant; examples:

Answer 9

infectious dose; shigella species and enteroinvasive E.coli

Question 10

____ to sequester iron in low iron environments (i.e. enterobactin produced by E.coli)

Answer 10

siderophores