Bacteriology - Mycology Intro Flashcards
Importance of fungi being eukaryotic
Key for drug use, eukaryotic cells of fungi are similar to host cells - drugs can attack both = toxic
Ergosterol
Replaces cholesterol in fungi cells, what “azol” drug target
Yeast formation
Unicellular fungus, spreads by budding
Hyphae
Filamentous form of fungus
Pseudohyphae
Chains of yeast could appear like hyphae
Mold formation
Fungus that grows as a mass of hyphae (mycelium)
Dermatophyte form
Fungus that causes ringworm (superficial infections of skin, hair, nails)
Endospores
Spores contained in a sac
Dimorphism fungus
Fungus that exists as yeast forms in animal tissue & as hyphae in environment
Broad vs narrow based budding yeast
Broad - two spheres in one spore
Narrow - bowling pin shape
Fruiting body
Produces many conidia, tiny & light for easy dispersion (like a dandylion)
Arthroconidia
Spores released during hyphal fragmentation, occurs in patients
Macroconidia
Growth of spores that occur in vitro
Factors that effect development of fungal disease (5)
Virulence factors, tissues affected, host immunity, geographic location, environment
Best diagnostic test for superficial fungi
Wet mount cytology
- 10% K hydroxide
- new meth blue