Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMB Test 3 > B7-082 Antipsychotics > Flashcards

B7-082 Antipsychotics Flashcards

1
Q

antipsychotic drugs are […] based on their tendency to produce neurological side effects

A

neuroleptics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

the original name of antipsychotics was […] which were used to quiet institutionalized mental patient

A

major tranquilizers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

positive symptoms of schizophrenia [2]

A

hallucinations (typically auditory)
delusions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pathogenesis of schizophrenia is unknown but thought to have […] and […] components

A

neurodevelopmental
heritable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

all antipsychotics are antagonists of

A

D2 dopamine receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what interaction contributes to the side effects of antipsychotics

A

other receptors a, ACh, histamine, etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

most important receptors of antipsychotics

A

D2
5HT

(but extensively interact with other receptors causing side effects)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

initial pharmacologic effects of antipsychotics [2]

A

sedation
decreased agitiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

antipsychotics improve […] symptoms of schizophrenia over weeks to months of treatment

A

positive

(very delayed effect, presents a problem with the Dopamine hypothesis of schizophrenia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

do older, “typical” antipsychotics improve negative symptoms of shizophrenia?

A

no

positive may see improvement over time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do antipsychotics cause parkinsonism?

A

blocks the striatal dopamine receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

extrapryramidal effects of antipsychotics [3]

A

dystonia
akathisia
Parkinsonian symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

[…] can help prevent the extrapyramidal effects of antipsychotics

A

anticholinergics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

antipsychotics cause increased prolactin release via inhibition of […] receptors

A

D2

(can cause amenorrhea, gynecomastia, and lactation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

newer antipsychotics cause significant […] gain

A

weight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

can cause metabolic syndrome, diabetes

A

olanzepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

can cause blurred vision and retinitis pigmentosum

A

thioridazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

neuroleptic malignant syndrome can be treated with

(fever, rigidity, myoglobinuria)

A

bromotriptine
dantrolene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

used to treat tardive dyskinesia

A

valbenazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

long term side effects of antipsychotics

A

tardive dyskinesias
perioral tremor
blood dyscrasias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

agranulocytosis can occur with long term used of […]

A

clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

any drugs that are sedative will have […] CNS effects

A

additive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

effective against positive, but not negative schizophrenia symptoms

A

typical antipsychotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

produce EPS and tardive dyskinesia

A

typical antipsychotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

typical antipsychotics: phenothiazines [3]

A

chlorpromazine
fluphenazine
thioridazine

26
Q

-azine

A

phenothiazines (typical antipsychotics)

27
Q

haloperidol and thiotixene are […] antipsychotics

A

typical

28
Q

[…] has the highest incidence of causing EPS

A

typical antipsychotics

29
Q

first antipsychotic drug

A

clorpromazine (phenothiazine)

(typical antipsychotic)

30
Q

all typical antipsychotics are […] agonists

A

D2

31
Q

no EPS or tardive dyskinesia

A

atypical antipsychotics

32
Q

atypical antipsychotics are […] antagonists

A

5 HT receptors (higher affinity)

(also D2, but lower affinity)

33
Q

prototypical atypical antipsychotic

A

clozapine

34
Q

activity at a broad spectrum of receptors

“busiest drug out there”

A

clozapine

35
Q

some effect on negative shizophrenic symptoms

A

clozapine (atypical antipsychotic)

36
Q

major side effect of clozapine

A

agranulocytosis

(approved for used ONLY in patients that are treatment resistant, must receive routine blood tests)

37
Q

approved only for treatment resistant patients who must receive regular blood tests

A

clozapine (atypical antipsychotic)

38
Q

newer “atypical” antipsychotics have significant […] antagonist activity

A

5HT2

39
Q

generally have an improved side effect profile

A

newer “atypical” antipsychotics

40
Q

atypical antipsychotics that produce less EPS and tardive dyskinesia

A

risperidone (causes EPS at high doses)
lerasidone
paliperidone

41
Q

high incidence of weight gain and metabolic syndrome [2]

A

olanzapine
quetiapine

(newer atypical antipsychotics)

42
Q

D2 partial agonist
5HT2 antagonist

A

aripriprazole

43
Q

generally less sedating than other antipsychotics

A

aripriprazole

(newer atypical antipsychotics)

44
Q

other uses of antipsychotics

A

management of agitation and psychotic symptoms

45
Q

antipsychotics can be used to treat […] but associated with increased risk of mortality

A

dementia

46
Q

antipsychotics can be used to treat alcoholic hallucinosis but only when

A

actively drinking

(when in withdrawal, can cause seizures)

47
Q

early side effects of haloperidol that occur in the first few weeks [2]

A

dystonia
Parkinsonism

48
Q

use of what medication requires monitoring for agranulocytosis?

A

clozapine

49
Q

olazapine and quetiapine have a low liability for causing EPS, but can cause [2]

A

weight gain
metabolic syndrome

50
Q

atypical antipsychotics 5-HT2 […] D2

[higher affinity for which receptor?]

A

5-HT2 > D2

51
Q

typical antipsychotics 5-HT2 orD2

[higher affinity for which receptor?]

A

5-HT2 < D2

52
Q

typical antipsychotics have a tendency to cause [2]

A

EPS (parkinsonism)
tardive dyskinesia

53
Q

antipsychotics with strong […] effects are the most likely to cause orthostatic hypotension and erectile dysfunction

A

alpha antagonist

(chlorpromazine)

54
Q

has the side effect of retinitis pigementosa

A

thiordazine

55
Q

which class of antipsychotics is more likely to cause EPS?

A

typicals

56
Q

delirium results from blockade of […] receptors

A

muscarinic

57
Q

erectile dysfunction and orthostatic hypotension results from blockade of […] receptors

A

alpha

58
Q

sedation results from blockade of […] receptors

A

histamine

59
Q

galactorrhea results from blockade of […] receptors

A

D2

60
Q

less likely to produce EPS than typical antipsychotics, but EPS can still occur at high doses

A

risperidone

61
Q

decrease EPS by blocking the input of cholinergic striatal interneurons to ascending GABAergic projection from the caudate to the globus pallidue

A

anticholinergics (benzotropine)

(used to lessen EPS)

BMB Test 3 (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions