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M&M Test 1 > B6-086 Statin Myopathy > Flashcards

B6-086 Statin Myopathy Flashcards

1
Q

painful muscle cramps, myoglobinuria with exercise, arrhythmia

A

McArdle’s

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2
Q

second wind phenomenon noted during exercise due to increased muscular blood flow

A

McArdle’s

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3
Q

repetitive injection sites can lead to

A

focal myopathies

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4
Q

common disease unmasked by statins

A

McArdles

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5
Q

myophosphorylase deficiency

A

McArdles

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6
Q

the more lipophilic statins are, the more they are associated with

A

myopathies

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7
Q

medication that was so bioavailable and lipophilic it has to be recalled due to unacceptably high rates of rhabdo

A

cerivastatin

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8
Q

common complication of rhabdomyolysis

A

AKI

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9
Q

any agent that significantly lowers cholesterol may precipitate a

A

statin-like myopathy

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10
Q

patients with […] may have enhanced susceptibility to statin associated myopathy

A

hypothyroidism

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11
Q

what lab changes might you expect to see in a patient admitted for rhabdomyolysis and AKI?

-[…]volemia
-[…]kalemia
-[…]phoshatemia
-[…]calcemia
-[…]uricemia
-metabolic […]

A

-hypovolemia
-hyperkalemia
-hyperphoshatemia
-Hypocalcemia
-hyperuricemia
-metabolic acidosis

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12
Q

glycogen not properly broken down in muscle

A

McArdles

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13
Q

cardiac dysrhythmias and arrest due to rhabdomyolysis are caused by

A

hyperkalemia

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14
Q

damages muscle membranes via the action of acetylaldehyde and free radicals

A

alcohol use disorder myopathy

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15
Q

type 2 fiber atrophy is associated with

A

alcohol use disorder myopathy

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16
Q

diseases unmasked by statins [4]

A

-hypothyroidism
-hypovitaminosis D
-renal failure
-obstructive liver disease

17
Q

statin cleared through kidneys

A

pravastatin

18
Q

concurrent use of what drugs increase the risk factor for statin myopathy [4]

A

glucocorticoids
cyclosporine
daptomycin
zidovudine

19
Q

proximal, symmetric muscle weakness/soreness that causes functional impairments onset with statin therapy

A

statin induce myopathy

20
Q

diagnosis of statin myopathy is dependent on both onset with […] and resolution with […]

A

initiation of statin therapy
withdrawal of statin

21
Q

-dense focal fibrosis
-scattered fiber necrosis
-inflammatory infiltration

A

focal myopathy

22
Q

what muscles are most commonly affected by focal myopathy?

A

deltoid and quadriceps

23
Q

-variation in fiber size and an increase in internal nuclei
-markedly elevated CK levels

A

necrosis/rhabdomyolysis

24
Q

you have a patient exhibiting signs of statin myopathy. you withdrawal the statin but they continue to have symptoms, what should you evaluate for?

A

hypothyroidism

M&M Test 1 (15 decks)

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