B6-086 Statin Myopathy Flashcards
painful muscle cramps, myoglobinuria with exercise, arrhythmia
McArdle’s
second wind phenomenon noted during exercise due to increased muscular blood flow
McArdle’s
repetitive injection sites can lead to
focal myopathies
common disease unmasked by statins
McArdles
myophosphorylase deficiency
McArdles
the more lipophilic statins are, the more they are associated with
myopathies
medication that was so bioavailable and lipophilic it has to be recalled due to unacceptably high rates of rhabdo
cerivastatin
common complication of rhabdomyolysis
AKI
any agent that significantly lowers cholesterol may precipitate a
statin-like myopathy
patients with […] may have enhanced susceptibility to statin associated myopathy
hypothyroidism
what lab changes might you expect to see in a patient admitted for rhabdomyolysis and AKI?
-[…]volemia
-[…]kalemia
-[…]phoshatemia
-[…]calcemia
-[…]uricemia
-metabolic […]
-hypovolemia
-hyperkalemia
-hyperphoshatemia
-Hypocalcemia
-hyperuricemia
-metabolic acidosis
glycogen not properly broken down in muscle
McArdles
cardiac dysrhythmias and arrest due to rhabdomyolysis are caused by
hyperkalemia
damages muscle membranes via the action of acetylaldehyde and free radicals
alcohol use disorder myopathy
type 2 fiber atrophy is associated with
alcohol use disorder myopathy
diseases unmasked by statins [4]
-hypothyroidism
-hypovitaminosis D
-renal failure
-obstructive liver disease
statin cleared through kidneys
pravastatin
concurrent use of what drugs increase the risk factor for statin myopathy [4]
glucocorticoids
cyclosporine
daptomycin
zidovudine
proximal, symmetric muscle weakness/soreness that causes functional impairments onset with statin therapy
statin induce myopathy
diagnosis of statin myopathy is dependent on both onset with […] and resolution with […]
initiation of statin therapy
withdrawal of statin
-dense focal fibrosis
-scattered fiber necrosis
-inflammatory infiltration
focal myopathy
what muscles are most commonly affected by focal myopathy?
deltoid and quadriceps
-variation in fiber size and an increase in internal nuclei
-markedly elevated CK levels
necrosis/rhabdomyolysis
you have a patient exhibiting signs of statin myopathy. you withdrawal the statin but they continue to have symptoms, what should you evaluate for?
hypothyroidism
