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M&M Test 1 > B6-006 CBCL Juvenille Idiopathic Arthritis > Flashcards

B6-006 CBCL Juvenille Idiopathic Arthritis Flashcards

1
Q

-common elbow injury in children <5 caused by a sudden pull on the arm.
-causes the immature annular ligament to slip over the head of radius

A

radial head subluxation (nursemaid’s elbow)

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2
Q

child holding their injured arm in slightly flexed and pronated position

A

radial head subluxation (nursemaid’s elbow)

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3
Q

overuse injury caused by repetitive strain and chronic avulsion of the proximal tibial tubercle

A

Osgood-Schlatter disease

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4
Q

-commonly occurs in adolescents following growth spurt or running/jumping athletes
-presents with progressive anterior knee pain

A

Osgood-Schlatter disease

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5
Q

-overuse injury that commonly presents in young, female athletes as anterior knee pain
-exacerbated by prolonged sitting or kneeling

A

patellofemoral syndrome

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6
Q

abnormal acetabulum development in newborns

A

developmental dysplasia of the hip

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7
Q

risk factor for developmental dysplasia of the hip

A

breech presentation

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8
Q

manipulation of newborn hip reveals “clunk”

A

developmental dysplasia of the hip

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9
Q

a diagnosis of developmental dysplasia of the hip can be confirmed via what imaging modality?

A

US

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10
Q

idiopathic avascular necrosis of the femoral head

A

Legg-Calve-Perthes

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11
Q

commonly presents between 5-7 years with insidious onset of hip pain that may cause the child to limp

A

Legg-Calve-Perthes

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12
Q

Legg-Calve-Perthes is more common in [males/females] and the intial Xray is often [normal/abnorma]

A

males
normal

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13
Q

classically presents in an obese young adolescent with hip/knee pain and altered gait

A

slipped capital femoral epiphysis

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14
Q

increased axial force on the femoral head causes epiphysis to displace relative to femoral neck

A

slipped capital femoral epiphysis

**ice cream falling off cone

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15
Q

slipped capital femoral epiphysis is diagnosed via what imaging modality?

A

Xray

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16
Q

systemic arthritis seen in <16 years of age

A

systemic juvenile idiopathic arthritis

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17
Q

daily spiking fevers, salmon-pink macular rash, arthritis

A

systemic juvenile idiopathic arthritis

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18
Q

systemic juvenile idiopathic arthritis is associated with what pathology of the eye?

A

uveitis

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19
Q

expected labs for systemic juvenile idiopathic arthritis

A

leukocytosis
thrombocytosis
anemia
elevated ESR
elevated CRP

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20
Q

disruption of blood flow to the femoral head

A

Legg-Calves-Perthes

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21
Q

congenital malformation of the acetabulum

A

developmental hip dysplasia

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22
Q

displacement of the epiphysis relative to the femoral head

A

slipped capital femoral epiphysis

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23
Q

dysregulation of the adaptive immune system

A

JIA

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24
Q

bone fragmentation at the tibial tuberosity

A

Osgood Schlatter

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25
Q

chrondrocalcinosis is associated with

A

pseudogout

26
Q

next step in management of slipped capital femoral epiphysis

A

surgical evaluation

27
Q

splint can be used in some case of

A

development hip dysplasia

28
Q

[…] is an important management strategy for patellofemoral pain

A

quadriceps strengthening

29
Q

next best step for JIA that is unresponsive to naproxen and only involves a single joint

A

intra articular steroid injection

30
Q

best treatment of oligoarticular JIA with systemic symptoms

A

methotrexate

31
Q

what medication can cause osteoporosis and be associated with fragility fractures?

A

prednisone

32
Q

common side effect of methotrexate

A

oral ulcers

33
Q

common side effect of anakinra

A

injection site reactions

34
Q

individuals with JIA are at high risk for […] and require consistent monitoring as it can present asymptomatically

A

uveitis

35
Q

immature annular ligament slipping over radial head

A

radial head subluxation

36
Q

treatment for radial head subluxation

A

manual reduction

37
Q

MOA: inhibition of dyhydrofolate reductase

A

methotrexate

38
Q

besides age, what can be helpful in distinguishing JIA from adult onset RA?

A

pattern of joint involvement

39
Q

most children with systemic JIA will require persistent use of […] to achieve remission

A

immunomodulatory therapy

40
Q

risk of uveitis is [higher or lower] in soJIA than other types of JIA

A

lower

41
Q

what percentage of patients with soJIA develop MAS?

A

10%

42
Q

immune dysregulation associated with infections or oncologic process

A

HLH

**the term MAS is reserved for patients with underlying rheumatologic disease

43
Q

[…] should prompt consideration that a patient with soJIA is progressing to MAS

A

hepatic dysfunction

44
Q

fever, rash, arthritis, and evidence of multiorgan dysfunction

A

MAS

45
Q

approximately 20% of MAS in soJIA occurs at time of

A

initial diagnosis

46
Q

first-line treatment for MAS

A

pulse dosing IV steroids

47
Q

MIS-C is associated with thrombo[…]

A

thrombocytopenia

48
Q

KD is associated with thrombo[..]

A

thrombocytosis

49
Q

used in refractory Kawasaki disease

A

inflixumab

50
Q

second-line treatment for MAS or MIS-C

A

anakinra

51
Q

what type of arthritis is associated with IL-1?

A

soJIA

52
Q

what type of arthritis is associated with TNFa?

A

oligoarticular and polyarticular JIA

53
Q

what type of arthritis is associated with IL-17?

A

psoriatic and ankylosing spondylitis

54
Q

1-4 joints impacted

A

oligoarticular

55
Q

JIA typically presents with […] involvement, while RA typically presents with […] involvement

A

JIA: oligoarticular
RA: polyarticular

56
Q

[…] can be seen in MAS due to the significant consumptive process and bone marrow involvement

A

thrombocytopenia

57
Q

Legg-Calve-perthes typically affects children in the age range of […]

A

5-7

58
Q

methotrexate can be used to treat [….]JIA

A

polyarticular JIA

59
Q

anakinra can be used to treat […] JIA

A

soJIA

60
Q

tenderness of the patella tendon

A

Osgood-Schlatter

61
Q

discomfort with patellar grind

A

patellofemoral syndrome

62
Q

hyperglycemia can be associated with what medication?

A

prednisone

M&M Test 1 (15 decks)

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