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M&M Test 1 > B6-007 CBCL Arthritis > Flashcards

B6-007 CBCL Arthritis Flashcards

1
Q

wear and tear destroys articular cartilage

A

osteoarthritis

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2
Q

inflammation induces formation of pannus which erodes articular cartilage and bone

A

rheumatoid arthritis

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3
Q

pain in weight bearing joints after use that improves with rest

A

osteoarthritis

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4
Q

asymmetric joint involvement, no systemic symptoms

A

osteoarthritis

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5
Q

in osteoarthritis, knee cartilage loss begins [medial/lateral]

A

medial

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6
Q

osteophytes

A

osteoarthritis

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7
Q

asymmetric joint space narrowing

A

osteoarthritis

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8
Q

subchondral sclerosis, cysts, and loose bodies

A

osteoarthritis

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9
Q

synovial fluid WBC <2000

A

osteoarthritis

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10
Q

spares MCP

A

osteoarthritis

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11
Q

morning stiffness lasting >1 hr

A

rheumatoid arthritis

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12
Q

juxta-articular osteopenia

A

rheumatoid arthritis

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13
Q

symmetric joint space narrowing and soft tissue swelling

A

rheumatoid arthritis

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14
Q

spares DIP and 1st CMC

A

rheumatoid arthritis

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15
Q

deposition of calcium pyrophosphate crystals within the joint space

A

pseudogout

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16
Q

associated with hemochromatosis, hyperparathyroidism, and joint trauma

A

pseudogout

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17
Q

chondrocalcinosis on xray

A

pseudogout

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18
Q

rhomboid crystals under polarized light

A

pseudogout

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19
Q

acute treatment of pseudogout

A

NSAIDs, colchicine, glucocorticoid

**same as acute gout

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20
Q

prophylaxis for pseudogout

A

colchicine

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21
Q

common pathogens causing septic arthritis [3]

A

S. aureus
Streptococcus
N. gonorrhoeae

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22
Q

synovial fluid WBC >50,000

A

septic arthritis

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23
Q

osteophytes are consistent with

A

OA

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24
Q

involvement of the MCP is typical of

A

RA

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25
Q

a synovial fluid count > 2000 WBC is consistent with […] arthritis

A

inflammatory

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26
Q

causes of secondary OA [4]

A

diabetic neuropathy
trauma
genetic conditions
metabolic causes

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27
Q

best recommendation for a patient with OA

A

graduated exercise plan

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28
Q

is there evidence that hyaluronic acid injections have good efficacy?

A

no

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29
Q

most common type of arthritis associated with the leading cause of disability

A

OA

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30
Q

crepitus is associated with

A

OA

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31
Q

three types of cartilage

A

hyaline
fibrocartilage
elastic cartilage

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32
Q

what type of cartilage is found in articular cartilage?

A

hyaline

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33
Q

what type of cartilage is found in the respiratory tract?

A

hyaline

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34
Q

what type of cartilage is found in the external ear, epiglottis, and eustachian tube?

A

elastic

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35
Q

what type of cartilage is found in intervertebral discs, minisci, and pubic symphsis?

A

fibrocartilage

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36
Q

the primary collagen type in articular cartilage is

A

type II

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37
Q

what type of collagen is found in hyaline and elastic cartilage?

A

type II

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38
Q

what type of collagen is found in bone, tendon, dentin, and skin?

A

type I

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39
Q

what type of collagen is found in fibrocartilage?

A

type I

40
Q

the collagen fibers in articular cartilage are arranged in […] anchored at the subchondral plate

A

overlapping arcades

41
Q

wolff’s law states

A

bone responds in the direction of stress

42
Q

damage to […] leads to surface fissures

A

type II collagen arcades

43
Q

loss of the collagen structure allows fissures to form in the articular cartilage which allows fluid to enter the bone creating

A

subchondral cysts

44
Q

complete loss of articular cartilage and exposure of underlying bone

A

eburnation

45
Q

what type of crystals are seen in OA?

A

calcium pyrophosphate dihydrate cystals

46
Q

eburnated bone shows pressure […]

A

necrosis

47
Q

damage to the tide mark is seen in

A

hemochromatosis

48
Q

invasion of blood vessels is seen in

A

RA

49
Q

what common factor leads to destruction of the joint in gout and septic arthritis?

A

inflammation

50
Q

surface erosion that leads to the damage of type II collagen fibers

A

OA

51
Q

hemarthrosis can be a cause of

A

secondary OA

**evaluate for hemophilia

52
Q

ANA is sensitive for

A

SLE

53
Q

a parvovirus IgM should be done with

A

initial symptoms

54
Q

fifth’s disease is associated with

A

parvovirus

55
Q

chondrocalcinosis/calcium deposition in cartilage structures

A

pseudogout

56
Q

stickler syndrome is a cause of secondary OA due to

A

collagen mutation

57
Q

next best step for a child presenting with joint hypermobility?

A

collagen mutation genetic testing

58
Q

best treatment for a child with hypermobility

A

physical therapy to strengthen muscles and improve joint mechanics

59
Q

cartilage degradation products that lead to propagation of osteoarthritis changes

A

DAMPs

60
Q

mediate cartilage degradation

A

MMPs

61
Q

pannus formation and synovial lining hyperplasia are consistent with

A

RA

62
Q

if a patient with OA does not respond to therapies and continues to have severe pain, what is the next best step?

A

referral to orthopedic surgery

63
Q

central erosion “gull wing” sign is associated with

A

erosive OA

64
Q

pencil in cup change is consistent with

A

psoriatic arthritis

65
Q

periarticular erosion
periarticular osteopenia
symmetric joint space narrowing

A

RA

66
Q

activation of osteoblasts due to decreased sclerostin results in increased […] causing bone formation

A

Wnt signaling,

67
Q

periarticular erosion is associated with

A

RA

68
Q

periarticular osteopenia is associated with

A

RA

69
Q

[…] is frequently seen in erosive osteoarthritis affecting the DIPs and PIPs

A

central erosion

70
Q

diabetic neuropathy is a risk factor for

A

secondary OA

71
Q
A

charcot joint due to diabetic neuropathy

72
Q

collapse of the midfoot with absence of pain

A

charcot joint

73
Q

medication that inhibits CD20 cells

A

rituximab

74
Q

inhibit phospholipase A2

A

corticosteroids

75
Q

chondrocyte proliferation is consistent with

A

OA

76
Q
A

CMC arthritis

77
Q

dactylitis is a common presentation of

A

psoriatic arthritis

78
Q

hook like osteophytes on the MCPs

A

hemochromatosis

79
Q

ulnar styloid erosion is associated with

A

RA

80
Q

[…] is indicated when there is high concern of internal derangement

A

MRI

81
Q

causes death of the vascular bone below the tidemark

A

avascular necrosis

82
Q

separation of the cartilage and bone at the level of tidemark is most commonly seen in

A

hemachromatosis

**iron accumulates at tidemark

83
Q

separation of the cartilage and bone at the level of the subchondral plate

A

avascular necrosis

84
Q

corticosteroids inhibit

A

phospholipase A2

85
Q

loss of proprioception leads ultimately to instability

A

charcot joint

86
Q

first line imaging study

A

Xray

87
Q

inhibitor of serotonin and norepinephrine

A

duloxetine

88
Q

junction of hyaline and calcified cartilage

A

tidemark

89
Q

subchondral plate is normally

A

thin

90
Q

subchondral bone is destroyed, so exposed bone is trabecular

A

RA

91
Q

in RA, the involvement of […] lining the tendon sheaths causes morning stiffness

A

synovium

92
Q

lymphocytes cause vessels to invade into the articular cartilage

A

RA

93
Q

in OA, as articular cartilage degrades, the subchondral bone

A

thickens

94
Q

in OA, the mixture of degradation and repair can lead to abnormal loading and cause […]

A

avulsion fractures

95
Q

in OA, avulsion injuries and repair leads to

A

osteophytes

M&M Test 1 (15 decks)

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