B6-007 CBCL Arthritis Flashcards
1
Q
wear and tear destroys articular cartilage
A
osteoarthritis
2
Q
inflammation induces formation of pannus which erodes articular cartilage and bone
A
rheumatoid arthritis
3
Q
pain in weight bearing joints after use that improves with rest
A
osteoarthritis
4
Q
asymmetric joint involvement, no systemic symptoms
A
osteoarthritis
5
Q
in osteoarthritis, knee cartilage loss begins [medial/lateral]
A
medial
6
Q
osteophytes
A
osteoarthritis
7
Q
asymmetric joint space narrowing
A
osteoarthritis
8
Q
subchondral sclerosis, cysts, and loose bodies
A
osteoarthritis
9
Q
synovial fluid WBC <2000
A
osteoarthritis
10
Q
spares MCP
A
osteoarthritis
11
Q
morning stiffness lasting >1 hr
A
rheumatoid arthritis
12
Q
juxta-articular osteopenia
A
rheumatoid arthritis
13
Q
symmetric joint space narrowing and soft tissue swelling
A
rheumatoid arthritis
14
Q
spares DIP and 1st CMC
A
rheumatoid arthritis
15
Q
deposition of calcium pyrophosphate crystals within the joint space
A
pseudogout
16
Q
associated with hemochromatosis, hyperparathyroidism, and joint trauma
A
pseudogout
17
Q
chondrocalcinosis on xray
A
pseudogout
18
Q
rhomboid crystals under polarized light
A
pseudogout
19
Q
acute treatment of pseudogout
A
NSAIDs, colchicine, glucocorticoid
**same as acute gout
20
Q
prophylaxis for pseudogout
A
colchicine
21
Q
common pathogens causing septic arthritis [3]
A
S. aureus
Streptococcus
N. gonorrhoeae
22
Q
synovial fluid WBC >50,000
A
septic arthritis
23
Q
osteophytes are consistent with
A
OA
24
Q
involvement of the MCP is typical of
A
RA
25
a synovial fluid count > 2000 WBC is consistent with [...] arthritis
inflammatory
26
causes of secondary OA [4]
diabetic neuropathy
trauma
genetic conditions
metabolic causes
27
best recommendation for a patient with OA
graduated exercise plan
28
is there evidence that hyaluronic acid injections have good efficacy?
no
29
most common type of arthritis associated with the leading cause of disability
OA
30
crepitus is associated with
OA
31
three types of cartilage
hyaline
fibrocartilage
elastic cartilage
32
what type of cartilage is found in articular cartilage?
hyaline
33
what type of cartilage is found in the respiratory tract?
hyaline
34
what type of cartilage is found in the external ear, epiglottis, and eustachian tube?
elastic
35
what type of cartilage is found in intervertebral discs, minisci, and pubic symphsis?
fibrocartilage
36
the primary collagen type in articular cartilage is
type II
37
what type of collagen is found in hyaline and elastic cartilage?
type II
38
what type of collagen is found in bone, tendon, dentin, and skin?
type I
39
what type of collagen is found in fibrocartilage?
type I
40
the collagen fibers in articular cartilage are arranged in [...] anchored at the subchondral plate
overlapping arcades
41
wolff's law states
bone responds in the direction of stress
42
damage to [...] leads to surface fissures
type II collagen arcades
43
loss of the collagen structure allows fissures to form in the articular cartilage which allows fluid to enter the bone creating
subchondral cysts
44
complete loss of articular cartilage and exposure of underlying bone
eburnation
45
what type of crystals are seen in OA?
calcium pyrophosphate dihydrate cystals
46
eburnated bone shows pressure [...]
necrosis
47
damage to the tide mark is seen in
hemochromatosis
48
invasion of blood vessels is seen in
RA
49
what common factor leads to destruction of the joint in gout and septic arthritis?
inflammation
50
surface erosion that leads to the damage of type II collagen fibers
OA
51
hemarthrosis can be a cause of
secondary OA
**evaluate for hemophilia
52
ANA is sensitive for
SLE
53
a parvovirus IgM should be done with
initial symptoms
54
fifth's disease is associated with
parvovirus
55
chondrocalcinosis/calcium deposition in cartilage structures
pseudogout
56
stickler syndrome is a cause of secondary OA due to
collagen mutation
57
next best step for a child presenting with joint hypermobility?
collagen mutation genetic testing
58
best treatment for a child with hypermobility
physical therapy to strengthen muscles and improve joint mechanics
59
cartilage degradation products that lead to propagation of osteoarthritis changes
DAMPs
60
mediate cartilage degradation
MMPs
61
pannus formation and synovial lining hyperplasia are consistent with
RA
62
if a patient with OA does not respond to therapies and continues to have severe pain, what is the next best step?
referral to orthopedic surgery
63
central erosion "gull wing" sign is associated with
erosive OA
64
pencil in cup change is consistent with
psoriatic arthritis
65
periarticular erosion
periarticular osteopenia
symmetric joint space narrowing
RA
66
activation of osteoblasts due to decreased sclerostin results in increased [...] causing bone formation
Wnt signaling,
67
periarticular erosion is associated with
RA
68
periarticular osteopenia is associated with
RA
69
[...] is frequently seen in erosive osteoarthritis affecting the DIPs and PIPs
central erosion
70
diabetic neuropathy is a risk factor for
secondary OA
71
charcot joint due to diabetic neuropathy
72
collapse of the midfoot with absence of pain
charcot joint
73
medication that inhibits CD20 cells
rituximab
74
inhibit phospholipase A2
corticosteroids
75
chondrocyte proliferation is consistent with
OA
76
CMC arthritis
77
dactylitis is a common presentation of
psoriatic arthritis
78
hook like osteophytes on the MCPs
hemochromatosis
79
ulnar styloid erosion is associated with
RA
80
[...] is indicated when there is high concern of internal derangement
MRI
81
causes death of the vascular bone below the tidemark
avascular necrosis
82
separation of the cartilage and bone at the level of tidemark is most commonly seen in
hemachromatosis
**iron accumulates at tidemark
83
separation of the cartilage and bone at the level of the subchondral plate
avascular necrosis
84
corticosteroids inhibit
phospholipase A2
85
loss of proprioception leads ultimately to instability
charcot joint
86
first line imaging study
Xray
87
inhibitor of serotonin and norepinephrine
duloxetine
88
junction of hyaline and calcified cartilage
tidemark
89
subchondral plate is normally
thin
90
subchondral bone is destroyed, so exposed bone is trabecular
RA
91
in RA, the involvement of [...] lining the tendon sheaths causes morning stiffness
synovium
92
lymphocytes cause vessels to invade into the articular cartilage
RA
93
in OA, as articular cartilage degrades, the subchondral bone
thickens
94
in OA, the mixture of degradation and repair can lead to abnormal loading and cause [...]
avulsion fractures
95
in OA, avulsion injuries and repair leads to
osteophytes
