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M&M Test 1 > B6-005 Pharmacotherapy of RA and Joint Pain > Flashcards

B6-005 Pharmacotherapy of RA and Joint Pain Flashcards

1
Q

side effects of NSAID

A

GI distress (nausea, diarrhea)

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2
Q

centrally acting, non-narcotic analgesic

A

acetaminophen

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3
Q

side effect of high efficacy opiod

A

constipation

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4
Q

protective effects of aspirin

A

-decreased incidence of myocardial ischemia
-protective against colon cancer

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5
Q

COX inhibition by aspirin is […] and […]

A

nonselective and irreversible

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6
Q

COX inhibition reduces [….] production

A

prostaglandin

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7
Q

inhibit the transcription of inflammatory gene products

A

corticosteroids

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8
Q

sequesters TNF-a cytokines with “decoy” receptors

A

etanercept

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9
Q

COX-2 selective inhibitor

A

celecoxib

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10
Q

contraindicated in cardiovascular patients due to increased risk of clotting

A

celecoxib

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11
Q

blocks the production of IL-2, IL-3 and TNF-a

A

cyclosporine

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12
Q

gout symptoms can be exacerbated by […] diuretics

A

thiazide

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13
Q

inhibits the chemotactic and phagocytic action of neutrophils

A

colchicine

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14
Q

most commonly used gout therapy

A

NSAIDs

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15
Q

indomethacin and other NSAIDs inhibit […] phagocytosis

A

urate crystal

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16
Q

have largely replaced colchicine as drug of choice for gout

A

NSAIDs

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17
Q

gout patients who have failed or cannot tolerate NSAIDs can be given

A

corticosteroids

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18
Q

beneficial to patients when just one or two large joints are affected

A

intra-articular steroid injection

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19
Q

good option in elderly people with many illness to manage who only have pain in one or two joints

A

intra-articular steroid injection

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20
Q

non selective NSAIDs [3]

A

aspirin
ibuprofen
indomethacin

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21
Q

COX-2 selective NSAID

A

celecoxib

22
Q

nonselective COX inhibitor that irreversibly inhibits COX and platelet aggregation

A

aspirin

23
Q

aspirin is most effective in reducing mild/moderate pain through reducing

A

inflammation

24
Q

can have antipyretic effect likely mediated by COX and IL-1 inhibition in the CNS

A

aspirin

25
Q

most common adverse effect of aspirin

A

gastric upset, ulcers

26
Q

nonselective COX inhibitor often prescribed in lower doses with analgesic but no anti-inflammatory efficacy

A

acetaminophen

27
Q

nonselective COX inhibitor that works particularly well for gout and ankylosing spondylitis

A

indomethacin

28
Q

incidence of cardiovascular thrombotic events is associated with […] inhibitors

A

COX2

29
Q

weak inhibitor of peripheral COX enzymes

A

acetaminophen

30
Q

causes direct CNS analgesic effects

A

acetaminophen

31
Q

acetaminophen is not […] at typical doses

A

anti-inflammatory

32
Q

danger of liver damage due to acetaminophen occurs at doses of

A

> 4g/day

33
Q

inhibits microtubule aggregation which disrupts leukocyte chemotaxis and phagocytosis

A

colchicine

34
Q

gout prophylaxis is usually initiated after […] of symptoms

A

greater than one year

**not used for intial, acute attacks

35
Q

xanthine oxidase inhibitors

A

allopurinol
febuxostat

36
Q

increase renal clearance of uric acid by inhibiting tubular absorption

A

probenecid

37
Q

probenecid can increase the risk of […]

A

kidney stones

38
Q

inhibits URAT1, preventing renal reabsorption of uric acid

A

lesinurad

39
Q

inhibits AICAR transformylase and thymidylate synthetase affecting polymorphonuclear chemotaxis

A

methotrexate

40
Q

decreases IgA and IgM rheumatoid factor production

A

sulfasalazine

41
Q

cell growth arrestor (G1 phase)

A

leflunomide

42
Q

purine synthesis inhibitor, supresses B and T cell function

A

azathioprine

43
Q

inhibits IL-1 and IL2 production in T cells

A

cyclosporine

44
Q

cross links DNA to prevent cell replication

A

cyclophosphamide

45
Q

gold compounds alter the capabilities of

A

macrophages

46
Q

Anti TNF agents

A

etanercept
infliximab
adalimumab

47
Q

b cell depleting agent

A

rituximab

48
Q

inhibits receptor-ligand co-stimulation of T cells

A

abatacept

49
Q

IL-1 inhibitor

A

anakinra

50
Q

IL-17 inhibitors used for psoriasis [2]

A

secukinumab
ixekizumab

51
Q

what class of drugs inhibits the transcription of genes that encode inflammatory proteins?

A

steroids

52
Q

strength of opioids

A

fentanyl > hydromorphone > oxycodone > morphine/methadone > meperidine > codeine

M&M Test 1 (15 decks)

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