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M&M Test 1 > B6-002 Arthritis > Flashcards

B6-002 Arthritis Flashcards

1
Q

arthritis without positive rheumatoid factor

A

seronegative spondyloarthritis

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2
Q

seronegative spondyloarthritis has a strong association with HLA[..]

A

B27

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3
Q

-asymmetric and patchy involvement
-may have associate skin/nail lesions

A

psoriatic arthritis

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4
Q

psoriatic arthritis is associated with a […] deformity of DIP on Xray

A

pencil-in-cup

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5
Q

symmetric involvement of the spine and sacroiliac joints

A

ankylosing spondylitis

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6
Q

associated with joint fusion, uveitis, and aortic regurgitation

A

ankylosing spondylitis

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7
Q

characteristic Xray finding of ankylosing spondylitis

A

bamboo spine

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8
Q

costovertebral and costosternal ankylosis may cause restrictive lung disease

A

ankylosing spondylitis

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9
Q

associated with Crohn’s or ulcerative colitis

A

inflammatory bowel disease

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10
Q

classic triad of reactive arthritis

A

conjunctivitis
urethritis
arthritis

**can’t see, can’t pee, can’t bend my knee

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11
Q

reactive arthritis is commonly associated with what pathogens? [6]

A

Shigella
Campylobacter
E. Coli
Salmonella
Chlamydia
Yersinia

**She Caught Every Student Cheating Yesterday and overREACTed

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12
Q

inflammatory arthritis
enthesitis
uveitis

A

reactive arthritis

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13
Q

if a patient is unresponsive to NSAIDs and prednisone, what is the next best step?

A

immunosuppressants

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14
Q

inhibits CD20

A

rituximab

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15
Q

inhibits CD80/86

A

abatacept

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16
Q

inhibits IL-6

A

tocilizumab

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17
Q

abdominal pain with findings of blood in stool

A

inflammatory bowel disease

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18
Q

best step to aid in diagnosis of IBD related arthritis?

A

colonoscopy

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19
Q

rates of association of HLAB27 are highest with [2]

A

ankylosing spondylitis
reactive arthritis

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20
Q

best test for psoriatic arthritis

A

CRP

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21
Q

if you can only get one test done on the synovial fluid aspirate, get [..]

A

culture

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22
Q
A

rheumatoid arthritis

**erosive changes to metacarpal head

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23
Q
A

psoriatic arthritis

**pencil in cup changes and DIP involvement

24
Q

aortic regurgitation
(diastolic murmur at right sternal border)

A

reactive arthritis

and ankylosing spondy

25
Q

painless ulcers of the glans penis

A

circinate balanitis

**reactive arthritis

26
Q

chalky deposition which can intermittently drain at first MTP

A

gout

27
Q

rubbery nodule on extensor surface

A

rheumatoid nodule

28
Q

skin involvement of gonorrhea

A

pustules

29
Q

C. dif can cause

A

reactive arthritis

30
Q

activated as a result of unfolded proteins

A

IL-17

31
Q

IL17 inhibition can be used to treat [2]

A

ankylosing spondylitis
psoriatic arthritis

32
Q

typically preceded by GI/GU infection 1-4 weeks earlier

A

reactive arthritis

33
Q

classic triad of reactive arthritis

A

arthritis, conjuctivitis, urethritis

34
Q

most common infections associated with reactive arthritis [2]

A

chlamydia
c. dif

35
Q

mucocutaneous manifestations of reactive arthritis [2]

A

-circinate balanitis
-psoriaform lesions

36
Q

cardiac manifestation of reactive arthritis

A

aortic regurgitation

37
Q

the only case where antibiotics are treatment for reactive arthritis is

A

chlamydia

38
Q

if synovial fluid WBC is less than 2000, think

A

noninflammatory

** OA, mechanical injury

39
Q

if synovial fluid WBC is greater than 2000,

A

inflammatory

40
Q

if testing for gonorhhea, you have to

A

call lab. it requires a different culture medium

41
Q

most common cause of inflammatory arthritis in young adult males

A

reactive arthritis

42
Q

rates of [….] association are higher in patients that require hospitalization

A

HLAB27

43
Q

theories related to HLAB27 [4]

A

-arthritogenic peptide
-molecular mimicry
-free heavy chain
-unfolded protein

44
Q

prior to administered corticosteroids, you should ensure there is not

A

active infection

45
Q

about 15-20% of people with reactive arthritis will develop

A

chronic, persistent arthritis

46
Q

treatment options for reactive arthritis that has progressed to chronic arthritis [3]

A

-sulfasalazine
-methotrexate
-TNF inhibitors

**similar to RA

47
Q

RA spares the […] back

A

lower

48
Q

sacroiliac joints and spine most prominently affected

A

ankylosing spondylitis

49
Q

over 90% of individuals with ankylosing spondylitis are […] positive

A

HLAB27

50
Q

DIP involvement with pencil-in-cup deformity

A

psoriatic arthritis

51
Q

IL-17 and IL-23 inhibitors work through the […] that is associated with HLAB27

A

unfolded protein response

52
Q

HLADR4 is associated with

A

rheumatoid arthritis

53
Q

has migratory joint involvement

A

gonococcal arthritis

54
Q

tenosynovitis
urethritis
pustules on skin

A

gonococcal arthritis

55
Q

is culture positive

A

gonococcal arthritis

M&M Test 1 (15 decks)

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