B5 - Homeostasis - Paper 2 Flashcards
What is body temperature controlled by (in the brain)?
Thermoregulatory centre - hypothalamus
Give the two ways we detect temperature of the body
Thermoregulatory centre in the brain detects blood temp
Skin detects skin temp and sends these signals to the thermoregulatory centre
Why is it important to maintain optimum body temperature?
To Maintain optimum enzyme activity
What is the main mechanism for control of homeostasis (general)
Negative feedback
Give one way body temp can be decreased once it reaches an above optimum temperature (not to do with blood vessels)
Sweat
How does sweat cool us down
Layer of liquid perspiration which evaporates taking heat energy away from the skin
How does shivering warm us up
Body movement = respiration = release of thermal energy
How does hair standing on end (goosebumps) help to warm up?
Traps body heat as a layer of air insulation
What controls the response of blood vessels to heat or cold
The hypothalamus
Give 2 things which happen if body is detected as too hot
Vasodilation of blood vessels close to the skin
Shunt vessels further from the skin constrict
What are shunt vessels?
Vessels below the skin (further from the surface than others)
Why does vasodilation of blood vessels close to the surface of the skin help to reduce body temperature
More blood is travelling through them
Heat is lost through radiation through the skin
What happens to blood vessels when too cold?
Vasoconstriction of blood vessels close to the skin
Shunt vessels further from the skin become dilated
How does vasoconstriction work to maintain body temperature
Diverting blood away from the skin means less heat is lost through radiation
Describe the reflex arc of stimulus to response on a hot day
Hot day->skin receptor->sensory neurone -> relay neurone (in spine) ->motor neurone -> gland effector (sweat)
What is the optimum temperature of the human body?
37 degrees
When talking about homeostasis in an exam always describe what?
Negative feedback loops
Why is it important to maintain blood glucose concentration?
Regulation of cellular respiration
High levels of blood glucose are poisonous
What organ is blood glucose concentration controlled by?
The pancreas
What is the name for the store of glucose?
Glycogen
How do you remember what glycogen is?
It has an e on it and glucose does as well but glucagon doesn’t have an e
Where is glycogen found?
Liver and muscles
What is insulin?
A hormone that increases the amount of glucose stored as glycogen
How do you remember what insulin goes to glucose?
Insulin ‘insulates’ the glucose as glycogen
What hormone breaks glycogen back into glucose?
Glucagon
How do you remember that glucagon breaks down glycogen to glucose?
GlucAgon Attacks the glycogen to make glucose
Explain a negative feedback loop for blood sugar levels (increase in glucose back to optimum)
Increase in blood sugar due to eating
Detected by pancreas
Increases insulin secretion (hence glucose stored as glycogen in muscle and liver)
Blood glucose levels decrease back to normal
Describe the negative feedback loop after a decrease in blood sugar levels (the going back to optimum)
Decrease in blood sugar due to exercise
Detected by pancreas cells
Increase in glucagon secretion (breaking down glycogen in liver/muscles back to glucose and glucose released into blood
Glucose increases back to normal
What is diabetes
When blood glucose levels can’t be regulated
True or false: type 1 diabetes is genetic
True
Give 5 issues with too much blood glucose
Toxic
Decreases blood vessel elasticity
Glucose left as deposits (atherosclerosis)
Miscarriage risk
Dehydration
What 2 negative effects can result from narrowing of blood vessels due to excessively high blood glucose concentrations
Impeding blood flow to the eyes
Could lead to nerves stopping sending signals
True or false: blood vessels also have to supply nerves with glucose and oxygen
Trye
What is another word for the process of glucose being left as deposits?
Atherosclerosis
What can atherosclerosis lead to?
CHD
Why can there be a miscarriage risk if blood glucose too high (2 details)
Less supply of oxygen for the baby
Excess amniotic fluid puts pressure on organs
Why does high blood glucose concentration lead to dehydration?(4 steps)
Kidneys usually take required amount of glucose out of urine to be retained
Can’t keep up with very high glucose concentrations
Excess glucose has to be expelled in high volumes of urine
Leading to dehydration
Type 1 diabetes is when ___cant produce any/enough ____ due to the destruction of ____ producing cells
The pancreas
Insulin
Insulin
Give 5 things type 1 diabetes could lead to
Kidney damage
Heart problems
Blindness
Nerve damage
Damage to circulation
Give 4 symptoms of type 1 diabetes
Tiredness
Losing weight
Passing lots of urine
Feeling very thirsty
Give 3 treatments for type 1 diabetes
Insulin injection/insulin pump (which monitors blood glucose levels and adjusts insulin to fit)
Healthy diet
Regular exercise
What is an insulin pump?
Monitors blood glucose levels and adjusts insulin injection to fit the requirement
What is type 2 diabetes?
Pancreas produces insulin but cells aren’t sensitive/don’t respond to it
Glucose uptake (into glycogen) doesn’t happen so blood glucose concentration stays high
True or false: symptoms and potential after effects of type 1 and type 2 diabetes are different
False - they are the same
Give 3 treatments for type 2 diabetes
Healthy diet
Exercise regimes
Oral medications to control blood glucose concentrations
Give 2 risk factors for type 2 diabetes
Obesity
Poor diet + minimal exercise
Digestion of proteins results in excess ____ ____ (which contain ____) which need to be excreted _____
Amino acids
Nitrogen
Safely
What is deamination?
The removal of an amino group from an amino acid
What is the main product after the deamination of an amino acid?
Ammonia
True or false: ammonia is highly toxic for the body
True
What is ammonia converted into following deamination?
Urea
How is urea excreted?
In urine
What is water potential?
The likelihood of water molecules to move by osmosis into or out of a solution
Give 3 ways water can be lost by the body
Breathing OUT (can’t just say breathing)
Sweat
Urine
During exhalation what leaves the body via the lungs
Water vapour
Give 3 things lost through the skin via sweat
Water, ions, urea
What 3 things are removed via kidneys through urine
Excess water, ions and urea
Give 2 things which the kidney does to regulate water, glucose, ion concentrations in the body
Filtration and selective reabsorption
Describe what happens when the kidney filters blood
All small molecules (water, glucose, urea, ions) filtered from blood by kidney
What is selective reabsorption?
Right amount of water and ions and glucose re absorbed back into the blood depending on the body’s needs
What are the kidney tubules?
The part of the kidney where filtration and selective reabsorption occurs
What is ADH?
Controls the amount of water re absorbed back into blood
What is ADH produced by?
Pituitary gland
More ADH = more/less permeable
More permeable
More permeable kidney tubules = more/less water reabsorbed into the blood and more/less water lost via urine
More
Less
What is water concentration in the blood detected by
The hypothalamus
Blood water concincreases = more/less ADH
Less ADH - less permeable tubules - more dilute urine
What is a dialysis machine?
Removes waste products and excess fluid from the blood
What is dialysis used for?
Kidney failure
What would happen if your kidneys failed and why?
Damage to several organs and organ systems/ eventually death because
- waste substances would build up
- water content uncontrolled
- ion levels uncontrolled
Give 2 necessary dietary changes while on dialysis
Avoid salty foods (prevent ion build up between dialysis sessions)
Limit fluid content (prevent water content being too high, diluting blood and increasing blood pressure)
Give the 5 stages of a dialysis machine
Arterial Blood leaves arm
Anticoagulants (blood thinners) administered to prevent clotting
Blood runs through dialysis machine
Clean blood runs through bubble trap to get rid of bubbles
Clean blood returns to the arm
Dialysis fluid has the ____ concentration of glucose and mineral ions as healthy blood but is _____ in ____ and ____
Same
Low
Salt
Urea
Excess salt and urea moves out of the blood into the dialysis fluid through a partially permeable membrane in a dialysis machine by _____
Diffusion (along a concentration gradient)
True or false: there is a net movement of glucose and mineral ions in a dialysis machine
False
What is the function of a dialysis machine?
Filter blood and maintain safe ion concentration in the blood by removing excess ions and waste substances such as urea
Give 2 disadvantages of dialysis
Requires 3 sessions per week per patient
Costs around £300 per session
Give 1 advantage of dialysis
Readily available
Give 1 advantage of kidney transplants
Long term solution to kidney damage + a one time operation
Give a disadvantage of kidney transplants
Take a long time to be found
As an exact tissue match has to be found
What is thyroxine
A hormone released by the thyroid gland
What is thyroxine released by
The thyroid gland
What does thyroxine control
Basal metabolic rate (rate of energy transfers/chemical reactions in cells)
What is TSH?
Thyroid stimulating hormone
What is TSH released by
The pituitary gland
What does TSH do?
Controls how much thyroxine the thyroid gland produces
Give the negative feedback loop of thyroxine and TSH
Thyroxine levels too high - TSH secretion stops to reduce thyroxine back to optimum
Thyroxine levels too low - TSH secretion increases to increase thyroxine back to optimum
What recognises that thyroxine levels are too high?
Hypothalamus
What is adrenaline released by?
The adrenal gland
Why is adrenaline released?
In response to stressful situations
What does adrenaline do?
Gets body ready for fight or flight
Give the reflex arc for the release of adrenaline and it’s physical effects
Brain detects fear/stress
Sends nervous impulse to the adrenal glands
Adrenal glands release adrenaline
This increases heart rate to increase supply of oxygen and glucose to brain and muscles
What does adrenaline do physically?
Increase heart rate to increase supply of oxygen and glucose to the brain and muscles
What is oestrogen secreted by?
Ovaries
Where is oestrogen secreted to?
The uterus
And pituitary gland
What is testosterone secreted by
The testes
Where is testosterone secreted to?
Sex organs
What does oestrogen control the development of?
Female secondary sexual characteristics
Give 3 examples of female secondary sexual characteristics
Menstruation every 28 days
Development of breasts
Widening of hips
(Puberty basically)
Give 3 examples of make secondary sexual characteristics
Muscle development
Hair growth
voice breaking
Sperm production
(Puberty basically)
How long is the menstrual cycle?
28 days
Days 1-7 of the cycle what happens?
Uterus lining shed through the vagina
Days 8-13 what happens?
Uterus lining rebuilds
What happens on day 14
Egg released from ovaries = ovulation
What happens days 15-28
Uterus lining stays thick
If the egg is fertilised then uterus lining stays __ and there is __- period
Thick
No
If it is not fertilised the egg ____ via the ____
Leaves
Period
What does FSH do?
Causes the egg to mature in the ovary
What is FSH produced by?
The pituitary gland
What does FSH stimulate?
Release of oestrogen from ovaries
What does oestrogen do?
Repairs and thickens uterus lining
What is oestrogen produced by?
The ovaries
What does oestrogen stop being produced?
FSH
Why does oestrogen stop the release of FSH?
So only one egg matures
What does oestrogen stimulate?
Stimulates the pituitary gland to release LH
What is LH triggered by?
Oestrogen
What is LH released by?
The pituitary gland
What does progesterone do?
Maintains uterus lining
What is progesterone produced by?
By the follicle (which releases the egg - its a yellow body)
It is then released by the ovaries
At the start of the cycle ___ is high as an egg is maturing in the ovaries?
FSH
After FSH is high at the start then ____ peaks, stopping ___ production so the egg matures and ____ the uterus lining
Oestrogen
FSH
Develops
After oestrogen peaks ___ peaks and the ___ is released
LH
Egg
After the egg is released then ___ peaks to maintain the ___ uterus lining
Progesterone
Thick
What type of contraceptive method is the combined pill?
Hormonal
Give 3 ways in which the combined pill works as a contraceptive
Leaves thick cervical music to stop sperm entering
Consistent high levels of oestrogen to stop FSH
Progesterone stops LH production
Oestrogen presence inhibits what?
FSH
Progesterone stops ___ production
LH
Give 4 advantages of the combined pill
Free on the NHS
99% effective
Reduces risks of some cancers
Makes bleeds light and regular
Give 5 disadvantages of the combined pill
Not effective if vomiting
Not 100% effective
Side effects
No STD Protectiom
Can increase risk of blood clots and some cancers
Give 3 possible side effects of the combined pill
Nausea
Headaches
mood swings
The progesterone only pill is a ___ method of contraception
Hormonal
Give 2 ways the progesterone only pill works as a contraceptive
Ensures thick cervical mucus
Prevents ovulation by limiting LH production