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GIR Test 2 > B5-055 CBCL Poisoning > Flashcards

B5-055 CBCL Poisoning Flashcards

1
Q
  • inhibits acetylcholinesterase causing an increase in acetycholine
  • salivation, bradycardia, miosis
A

organophosphates

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2
Q

what is the best antidote for organophosphate overdose?

A

atropine

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3
Q

which antidote blocks muscarinic receptors and decreases constant stimulation by ACh?

A

atropine

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4
Q

classic signs of anticholinergic OD

organophosphates and carbamates

A

Salivation
Lacrimations
Urination
Defecation

SLUD

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5
Q

what is the major long term effect of arsenic poisoning?

A

cancer

bladder, skin and liver

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6
Q

which major organ system is more affected in children with chronic lead exposure?

A

CNS

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7
Q

causes developmental delays, behavioral issues, and learning/memory problems in children

A

lead

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8
Q

what is the major effect of dietary supplements on prescription medicines?

A

changes in pharmacokinetics

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9
Q

St Johns wart is an […] of CYP34A and p-gp

A

inducer

faster metabolism

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10
Q
  • parethesia
  • muscle twitching
  • ataxia
  • hearing/vision impairment
  • dark line on gums

pick your poison :)

A

mercury

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11
Q

what type of poisoning is associated with high fresh water fish diets?

A

mercury

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12
Q
  • vomiting
  • abdominal pain, diarrhea
  • numbness
  • tingling of extremeties
  • muscle cramping

pick your poison :)

A

acute arsenic

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13
Q
  • nausea, vomiting, diarrhea
  • abdominal pain
  • flu-like symptoms
  • kidney damage

pick your poison :)

A

cadmium

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14
Q
  • headaches
  • numbness in feet and legs
  • personality changes
  • anemia

pick your poison :)

A

lead

adults

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15
Q
  • headaches
  • eye issues
  • sore throat
  • anxiety, irritability
  • insomnia
  • memory loss
  • hand tremors

pick your poison :)

A

manganese

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16
Q

used for organophosphate poisoning but contraindicated for carbamates

A

2-PAM

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17
Q

what antidote is a strong anticholinergic with both central and peripheral actions?

A

atropine

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18
Q

used to treat both organophosphate and carbamate poisoning

A

atropine

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19
Q
  • headache
  • dizziness
  • confusion
  • weakness
  • feeling ill

pick your poison :)

A

carbon monoxide

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20
Q

treatment for carbon monoxide poisoning

A

oxygen
hyperbaric oxygen

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21
Q

which poison is treated with chelating agents such as succimer?

A

lead

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22
Q

[…] oxidize the iron component of RBCs rendering them unable to carry oxygen

A

nitrates

methemoglobin

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23
Q

methemoglobin should be treated with

A

methylene blue

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24
Q

characteristic pale to blue-gray color of skin

A

methemoglobin

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25
Q

succimer is used to treat […] poisoning

A

lead

`

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26
Q

what test should be ordered in a child exibiting behavioral/learning problems, anorexia, constipation and neuromuscular weakness?

A

blood lead level

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27
Q

erythrocytic stippling

A

lead poisoning

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28
Q

CaNaEDTA is used to treat

A

lead poisoning

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29
Q

what is the antidote for cyanide poisoning?

A

amyl nitrate

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30
Q

used to treat nitrate poisoning

A

methylene blue

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31
Q

used to treat ethylene glycol and methanol poisoning

A

fomepizole

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32
Q

used to treat acetaminophen toxicity

A

acetylcysteine

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33
Q

cholinesterase inhibitor used to treat toxicity by anticholinergic agents

A

physostigmine

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34
Q

used for organophosphate poisoning

2

A

atropine
2-PAM

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35
Q
  • anticholinergic that does not cross BBB
  • used for dilation of pupil during opthalmic examination
A

methylatropine

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36
Q

[…] poisoning results in significant renal damage

A

mercury

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37
Q

can cause nephrogenic diabetes insipidus

A

lithium

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38
Q

used to treat arsenic/gold poisoning, mercury poisoning, and lead poisoning

A

dimercapol

39
Q

ferrous sulfate poisoning is treated with

A

deferoxamine

40
Q

lithium toxicity is treated with

A

supportive care
diazepam for seizures

41
Q

manganese toxicity is treated with

A

disodium EDTA

42
Q

uncontrolled diarrhea, urination, sweating, constricted pupils

pick your poison :)

A

organophosphates

43
Q
  • abdominal pain
  • irritability
  • generalized weakness
  • loss of appetite
  • jaundice
  • diarrhea, nausea, vomiting

pick your poison :)

A

acetaminophen

44
Q
  • tinnitus
  • hyperventilation
  • vomiting
  • fever
  • diplopia
  • feeling faint

pick your poison :)

A

aspirin

45
Q
  • confusion
  • urinary retention
  • tachycardia
  • blurry vision
  • dry mouth
  • irritability
  • hallucinations

pick your poison :)

A

diphenhydramine

46
Q
  • severe dizziness, fainting
  • hallucinations
  • tachycardia, irregular beat
  • slow shallow breathing
  • vomiting
  • seizures

pick your poison :)

A

phenylephrine

47
Q
A
48
Q
  • weakness
  • vomiting, diarrhea
  • peripheral sensory neuropathy in glove/stocking pattern
  • loss of hair
  • hyperpigmentation
  • Mee’s lines on nails
  • QT prolongation
  • personality change

pick your poison :)

A

arsenic

49
Q
  • cough
  • sore nose/throat
  • weight loss
  • labored breathing
  • anorexia
  • fatigue

pick your poison :)

A

beryllium

50
Q
  • flu-like symptoms
  • osteomalacia
  • gout
  • respiratory, renal, liver damage

pick your poison :)

A

cadmium

51
Q
  • GI symptoms
  • memory loss
  • kidney failure
  • wrist/foot drop
  • dark line on gums

pick your poison :)

A

lead

varies based on age

52
Q
  • metallic taste in mouth
  • numbness/tingling in the hands/feet
  • mood swings
  • irritability
  • kidney damage
  • tremors/rashes
  • dark line on gums
A

mercury

53
Q

organophosphate
carbamates
physotigmine
nicotine

are all..

A

anticholinergic agents

cause SLUD symptoms

54
Q
  • abdominal pain
  • nausea, vomiting
  • headache
  • weakness
  • leg cramps
  • anemia

pick your poison :)

A

lead

55
Q
  • headache
  • dizziness
  • weakness
  • vomiting
  • diarrhea
  • confusion
  • angina
  • seizures

pick your poison :)

A

carbon monoxide

56
Q
  • stomatitis
  • emotional instability
  • hallucinations
  • delusions
  • course, jerky movements

pick your poison :)

A

mercury

57
Q
  • vomiting
  • abdominal pain, diarrhea
  • numbness
  • tingling of extremities
  • muscle cramping

pick your poison :)

A

arsenic

58
Q
  • nausea, vomiting
  • diarrhea, abdominal pain
  • flu-like symptoms
  • kidney damage

pick your poison :)

A

cadmium

59
Q
  • headaches
  • numbness in feet/legs
  • personality changes
  • anemia

pick your poison :)

A

lead

60
Q
  • headaches
  • eye issues
  • sore throat
  • anxiety
  • irritability
  • insomnia
  • memory loss
  • hand tremors

pick your poison :)

A

manganese

61
Q
  • irritability
  • memory loss
  • shyness, depression
  • uncontrable blushing
  • insomnia
  • tremor
  • gingivitis
  • stomatitis

pick your poison :)

A

mercury

62
Q
  • vomiting, abdominal pain
  • diarrhea
  • numbness, tingling of extremities
  • muscle cramping
  • death in extreme cases

pick your poison :)

A

arsenic

63
Q
  • nausea, vomiting, diarrhea
  • abdominal pain
  • flu like symptoms
  • kidney damage

pick your poison :)

A

cadmium

64
Q

used to alkalize the urine to increase the excretion of weak acids

A

sodium bicarbonate

65
Q

calcium gluconate is used to treat

A

manganese toxicity

66
Q

deferoxamine is used to treat

A

iron overdose

67
Q

dimercapol is used to treat

4

A

arsenic
gold
mercury
lead poisonings

68
Q

peripheral neuropathy and Mee’s lines are signs of

A

arsenic poisoning

69
Q
  • vomiting
  • hematemesis
  • hypotension
  • melena
  • coma
  • jaundice

pick your poison :)

A

copper

70
Q

indicated for oral ingestion of potentially life-threatening substances while the agent is still in the stomach

A

gastric lavage

71
Q

used to treat seizures

A

diazepam

72
Q

indicated when time since ingestion is less than 2 hr

A

activated charcoal

73
Q

can replace calcium in bones and gums

A

mercury

74
Q
  • loose teeth
  • tremors
  • uncontrollable blushing
  • hallucinations
  • delusions

pick your poison :)

A

mercury

75
Q
  • headaches
  • eye issues
  • sore throat
  • anxiety
  • irritability
  • insomnia
  • memory loss
  • hand tremors

pick your poison :)

A

manganese

76
Q
  • skin pigmentation changes
  • palmar and plantar hyperkeratosis
  • GI symptoms
  • anemia
  • liver disease

pick your poison :)

A

arsenic

77
Q
  • effects bone marrow
  • decreased RBCs
  • excessive bleeding
  • decreased immune response

pick your poison :)

A

benzene

78
Q
  • abdominal pain
  • colic
  • constipation

pick your poison :)

A

lead

79
Q

basophillic erythrocyte stippling

A

lead poisoning

80
Q

elevated erythrocyte proporphyrin

A

lead poisoning

81
Q

is organic or inorganic aresenic more toxic?

A

inorganic

82
Q

dilated pupils

A

mydriasis

83
Q

pinpoint pupils

A

miosis

84
Q

classic toxidrome for amphetamine overdose

A

mydriasis
hypertension
tachycardia
seizure

85
Q
  • tachycardia
  • dry mouth
  • OT prolongation with torsade

pick your poison :)

A

amitriptyline

86
Q
  • tachycardia
  • hypertension
  • hyperthermia
  • tachypnea
  • mydriasis
  • diaphoresis
  • seizures
  • psychoses

pick your poison :)

A

amphetamines

87
Q
  • nausea, vomiting
  • agitation
  • tremors
  • drowsiness
  • rapid eye movements
  • tachycardia
  • seizures

pick your poison :)

A

fluoxetine

88
Q
  • bradycardia
  • dizziness
  • trembling

pick your poison :)

A

beta blockers

89
Q

plotted to determine the percent of a specific cohort that is affected by a specific end point at a given dose

A

quantal

90
Q

refers to biphasic dose response to an enviornmental agent characterized by a low dose stimulation or beneficial effect and a high dose inhibitory/toxic effect

A

hormetic

91
Q

used to determine dose dependent increase in toxicity to number of doses

A

individual response curve

92
Q

curve that has little to no lag phase and intersects the x axis close to the origin

A

non-threshold response curve

93
Q

calculation for therapeutic index

A

TI=TD50/ED50

GIR Test 2 (18 decks)

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