Atropine Sulfate

Question 0

Mechanism of Action

Answer 0

CV: Increased heart rate, Increased conduction velocity, increased force of contraction, increased cardiac output
RESP: Decreased mucus production, increased bronchodilation
GI: Decreased GI secretion and motility
GU: Decreased urinary bladder tone
Misc: Mydriasis, decreased sweat production

Question 1

Class

Answer 1

Anticholinergic Agent, Antidote, Antispasmodic agent, Antiarrhythmic, Antimuscarinic

Question 2

Indications and Field Use

Answer 2

Symptomatic Bradycardia (sinus, junctional, and AV blocks causing significant hypotension, ventricular ectopy, cheat pain, ALOC)
Acetylcholinesterase inhibitor poisoning

Question 3

Adverse Reactions

Answer 3

Major: Tachydysrhythmias, flushing, ventricular irritablility, exacerbation/initiation of angina
Minor: Dry mouth,/mucous membranes, loss of taste, nausea, vomiting, urinary retention, weakness, hyperthermia

Question 4

Adult Dosage

Answer 4

Symptomatic Bradycardia: IV-0.5mg every 5 min. Do NOT exceed 3mg or 0.04mg/kg
Organophosphate or Carbamate Poisoning: IV-1-5mg, doses should be doubled every 5 min. IM-administer 2mg, 2 additional doses repeated in 10 min not to exceed 6mg.

Question 5

Dosage Forms/Packaging

Answer 5

IV Solution: 0.05mg/mL (5mL)
                   0.1mg/mL (5mL, 10mL)
                   0.4mg/0.5mg (0.5mL)
                   0.4mg/mL (0.5mL, 1mL, 20mL)
                   1mg/mL (1mL)