Adenosine

Question 0

Class

Answer 0

Antiarrhythmic, Endogenous Nucleoside

Question 1

Brand Name

Answer 1

Adenocard

Question 2

Mechanism of Action

Answer 2

Slows conduction time through the AV node; can interrupt re-entrant pathways through the AV node
Slows sinus rate
Larger doses decrease BP by decreasing peripheral resistance

Question 3

Indications and Field Use

Answer 3

Conversion of Supraventricular Tachycardias with no known Atrial Fibrillation or Atrial Flutter
Wide complex tachycardias of uncertain origin unresponsive to Lidocaine

Question 4

Contraindications

Answer 4

Sick sinus syndrome, 2nd or 3rd degree AV blocks; except pt with functioning ventricular pacemaker
Use cautiously in pt with known Asthma
Pts on theophylline and methylxanthines
Pts on Persantine or Tegretol
A Fib/A Flutter
Pregnancy

Question 5

Adverse Reactions

Answer 5

CV: Transient dysrhythmias, Palpitations, chest pressure, chest pain, hypotension, transient hypertension, facial flushing, sweating
RESP: Dyspnea, hyperventilation, tightness in throat, bronchospasm
CNS: Lightheadedness, headache, dizziness, paresthesias, apprehension, blurred vision, neck/back pain
GI: Nausea, metallic taste

Question 6

Adult Dosage

Answer 6

Initial: 6mg rapid IV bolus over 1-3 seconds, followed immediately with a 20cc NS flush. IV site recommended is AC, use injection port nearest hub of IV catheter.
Repeat: If no response in 1-2min may repeat with 12mg, twice, with same procedure for repeat dose
MAX 30MG

Question 7

Route of Administration, Onset of Action, Peak Effects, Duration of Action, Dosage forms/packaging

Answer 7

Rapid IVP, Seconds, Seconds, 10-12 seconds (5-7 sec half life), Flip top vials 6mg/2ml or Prefilled syringe 6mg/2ml