Asthma: Cellular

Question 1

Asthma is characterized by variable airflow ___, airway ___ to histamines, and chronic airway ___

Answer 1

Asthma is characterized by variable airflow obstruction, airway hyperresponsiveness to histamines, and chronic airway inflammation

Question 2

How would asma affect this volume curve?

Answer 2

FVC will lower, and FEV will lower. Therefore, the ratio will be low 70%, indicating an obstructive airflow disease.

It should revese with a drug or removal of trigger

Question 3

Answer 3

severe asthma

Question 4

during a methylcholine challenge test, if the FEV1 drops, we know that the person has:

Answer 4

airway hyperresponsiveness

Question 5

2 types of noneosinophilic asthma phenotypes

Answer 5

1. paucigranulocytic
2. neutrophilic

Question 6

2 types of eosinophilic asthma– which one is eligible for biolgics treatment?

Answer 6

1. eosinophilic– may indicate inadequate corticosteroid therapy, but its what’s considered “Typical Asthma”
2. mixed granulocytic. – eligible for biologics treatment

Question 7

NOTE: SABA on demand was a first line therapy prn. But now it’s an ICS/LABA on demand.

Question 8

note

Question 9

note: eosinophilic asthma can be treated with steroids, and severe cases with biolgics/ IL inhibitors. paucigranulocytic asthma is more steroid resistance, with some affect with LABAs. Bronchial thermoplasty might need to be considered.

Question 10

how do corticosteroids affect inflammatory cells

Answer 10

reduces eosinohphils, reduces cytokines from t cells, reduces number of mast cells, reduces cytokines from macrophages, and reduces dendritic cells.