Asthma Flashcards
What are the traits of asthma?
Variable degree of airway obstruction
Bronchial hyperresponsiveness
Mostly, airway inflammation
What are the steroid insensitive cells
Th17
Lymphocytes
Neutrophils
What are the steroid sensitive cells
Eosinophils Mast cells Th20lymphocytes Dendritic cells IL-4, -5, -13
Name asthma triggers
Infection to respiratory tract, virus Allergens Pollutant Medications (aspirin, beta-blocker) Exercice Cold air Physiological factors (stress, gastro-oesophageal reflux, sinus disease, obesity)
What is the criteria for a asthma diagnosis?
Following administration of a bronchodilator (like as salbutamol):
1- Improvement in FEV1 of at least 12% AND
2- at least 200ml within 30min
What is an acceptable daytime symptoms for asthma?
4 times/week
What is an acceptable nightime symptoms for asthma?
Once per week
What are the acceptable FEV1 or PEF ratios for asthma?
85% or above
How can you distinguish asthma from COPD?
Patient is young Has allergy Has nocturnal symptoms FEV1 is reversible Variable dyspnoea Responsive to steroids
What is SABA? Give examples of that drug
Short-acting bronchodilator
Examples:
- Beta-2 agonist
- anticholinergics
What are the best treatment against asthma?
Inhaled corticosteroids (‘‘-ids’’, ‘‘-ones’’)
At which step should you conduct combination therapies?
At step 3
