ASMA E BPCO Flashcards

1
Q

Farmacocinetica antileucotrieni

A

Somministrati per OS
Metabolizzati da CYP450 e CYP2C9
ADR Sindrome di Churg strauss e raramente epatopatie

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2
Q

Zileuton

A

Inibisce i 5-LT
Cyp450

Viene glucoronato

Eliminazione urine e feci

Interazione con Teofilina e Warfarin

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3
Q

Lukast
Zafirlukast

A

Antagonista recettore LTD4

Cyp450 cyp2c9

Urine 10% feci 90%

Interazione con wargarin, teofilina, eritromicina, aspirina,

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4
Q

Montelukast

A

Inibisce recettore LTD4

Cyp450 cyp3a4

Feci urine

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5
Q

Cromoni

A

Cromoglicato
Nedocromile

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