ARTRITIS REUMATOIDE Flashcards

1
Q

QUE ES?

A

ENF AI, SISTEMICA, CRONICA Y POLIART.

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2
Q

ETIOLOGIA

GEN HLA

A
  • GEN HLA > MHC
  • RECONOC PROTS CITRULINADAS; ARGININA SE MODIFICA Y FAVORECE LA APARICION DE PEPTIDOS CITRULINADOS > ACTIVA LINFOCITOS T > ATACA TODAS PROTS CON PEPTIDO CITRUL
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3
Q

TH17

A

EL PPL INFOCITO PRODUCIDO > IL17> GRAN RESP INL EN LA ARTICULACION> CEL DENDRITICA, MACROF Y LB> CATABOLISMO OSEO
CITOQUINAS Y FACTORES DE CREC> FIBROBLASTOS> RANKL> OSTEOCLASTO> DESTRUCCION MO

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4
Q

PANNUS

A

PROLIFERACION ANORMAL DE CELS DE LA VAINA SINOVIAL, DEPOSIT SOBRE EL CART ARTICULAR > DEGRADACION MO

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5
Q

FIBROBLASTO

A

UPREGULATION ONCOGENES; ADQU FENOTIPO TUMORAL DONDE PROLIFERAN MUCHO.

  • SECRECION CITOQUINAS, METALOPROT Y CATEPSINAS (PROTEASAS INESP)
  • RANKL Y VEGF
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6
Q

OSTEOART VS AR

A

OA: INF CART ART
AR: ENF AI X INFILTRACION

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