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MSK > Arthritis - Osteoarthritis and Rheumatoid > Flashcards

Arthritis - Osteoarthritis and Rheumatoid Flashcards

1
Q

Osteoarthritis

A

Most common arthritis

Degenerative disease of joints resulting in loss of articular cartilage, remodelling of adjacent bone and inflammation

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2
Q

Osteoarthritis Epidemiology

A

> 40

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3
Q

Osteoarthritis Characteristics

A 
Degenerative
Loss of joint space
Osteophytes
Subchondral sclerosis
Subchondral cysts
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4
Q

Osteoarthritis Symptoms

A

Painful and stiff with restricted movement

Pain

  • Gradual onset
  • Worse on exercise
  • Less than 30 minutes in the morning
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5
Q

Osteoarthritis Common Sites

A

Large weight bearing joints

DIPs

Spinal Cord
- Sciatica

Can be unilateral

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6
Q

Osteoarthritis Treatment

A 
Analgesia
NSAIDs
Steroids
Education
Weight loss
Physiotherapy
Arthroplasty (constant pain and limited movement)
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7
Q

Rheumatoid Arthritis

A

Symmetrical Inflammatory Arthritis

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8
Q

Rheumatoid Arthritis Epidemiology

A

Females

Adults any age

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9
Q

Rheumatoid Arthritis Common Sites (4)

A

Synovium of Joints
Peripheral Joints
PIPs
MCPs

Systemic Effect

  • Lungs
  • Heart
  • GI
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10
Q

Rheumatoid Arthritis Characteristics

A

Autoimmune

HLA-DR4 mediated

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11
Q

Rheumatoid Arthritis Triggers

A

Stress
Infection
SMoking

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12
Q

Rheumatoid Arthritis Hallmarks (4)

A

Synovitis
Tenosynovitis

Pannus Formation
- Inflamed spongy synovial as a result of inflammation and hypertrophy

Bony Erosions
- Increased Osteoclast Activity

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13
Q

Rheumatoid Arthritis Inflammatory Markers (3)

A

CRP
ESR
PV

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14
Q

Rheumatoid Arthritis Classifications

A

Early: <2 years after symptom onset

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15
Q

Rheumatoid Arthritis Mucocutaneous Involvement

A 
Alopecia
Oral/ nasal ulceration
malar rash
Photosensitivity
Systemic sclerosis
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16
Q

Rheumatoid arthritis respiratory involvement

A

Pneumonitis (methotrexate use)
Pulmonary Fibrosis
Pleural Effusions (cough and SOB)

17
Q

Rheumatoid Arthritis CV involvement

A 
Raynauds
Valvulitis
Endocarditis
Pericarditis
LVF
18
Q

Rheumatoid Arthritis Renal Involvement

A

Glomerulonephritis (asymptomatic until severe)

19
Q

Rheumatoid arthritis eye involvement

A

Scleritis
Anterior uveitis
Dry eyes

20
Q

Rheumatoid Arthritis Antibodies

A

Anti-CCP (most specific)

Rheumatoid factor

21
Q

Rheumatoid Arthritis Investigations

A

MRI
DAS28
- <2.6= remission
->5.1 = Severe active RA

22
Q

Rheumatoid Arthritis Treatment

A

Methotrexate
Sulfasalazine

Biologics

  • If 2 DMARDs unsuccessful
  • DAS28 >5.1 on 2 occasions 4 weeks apart

MSK (35 decks)

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