Aromatic Chemistry 4

Question 1

friedel crafts alkylation provides the most …

Answer 1

direct route to alkylbenzenes

Question 2

carbocation rearrangements limit ..

Answer 2

synthetic utility

Question 3

give examples of phenol derived drugs?

Answer 3

• aspirin
• viagra
• levodopa

Question 4

fused ring drug eg

Answer 4

• codeine
• morphine
• heroin

Question 5

after friedel crafts acylation, alkyl benzene can be prepared in one of 3 ways

what are these possible ways?

Answer 5

• clemmensen reduction
• catalytic hydrogenation
• wolff-kishner reaction

Question 6

eg of important alkyl benzene derivatives

Answer 6

• mescaline

- methamphetamine

Question 7

a benzyl radical is unusually …

Answer 7

stable

Question 8

what can aryl bromides and iodides be converted to?

Answer 8

Grignard reagents / lithium salts

Question 9

what do Grignard reagents / lithium salts behave like?

Answer 9

aryl anions

Question 10

grignard reagents and lithium salts are both …

what does this mean?

Answer 10

strong bases

will be deactivated if any acidic functionality is present

Question 11

Grignard reagents can be made in the presence of …

Answer 11

chloro group

Question 12

what can Grignard reagents be used as?

Answer 12

nucleophiles

Question 13

eg of important benzylalcohols

Answer 13

• adrenaline

- ephedrine

Question 14

ketones are produced under …

Answer 14

mild conditions

Question 15

benzoic acids are obtained with … reagents

Answer 15

stronger

Question 16

tertiary alkyl substituted benzenes are …

Answer 16

unreactive

Question 17

how can we produce benzoic acid without an alcohol?

Answer 17

key formation of benzylic cation

Question 18

aniline can react with acid chlorides to give …

Answer 18

amides and carbonyl compounds which then give imines

Question 19

imines formed from aniline are less reactive than alkyl amines

how so?

Answer 19

conjugation of nitrogen lone pair with benzene ring