APEX: VALLEY PHARMACODYNAMICS Flashcards
Pharmacodynacmis is the study of
Effect site concentration and CLINICAL EFFECT
Describes the relationship between the DRUG DOSE AND PLASMA CONCENTRATION
Pharmacokinetics
Pharmacobiophasics unites
Pk and PD by examining the relationship between plasma concentration and effect site concentration
Pharmacokinetics studies primarily 2 things
Drug dose
Plasma concentration
Pharmacobiophasics studies primarily 2 things
Plasma concentration
Effect site concentration
Pharmacodynamics studies primarly 2 things
Effect site concentration
Mnemonic to remember each pharmk,pharmB, PharmD
KBD
DPEC
What the body does to the drug
Pharmakinetics
Relationship is affected by
ADME
The biophase aka
Effect site
What the drug does the body
Pharmacodynamics
Pharmacodynamics concepts
PEDAPIA LETS
Potency Efficacy Dose response curve slope Agonist Partial Agonist Inverst agonist Antagonist LD50 ED50 Therapeutic index Stereochemistry
On the dose response curve, the x-axis correlates with:
Potency
Dose requires to achieve a given clinical effect
potency
Intrinsic ability of a drug to elicit a given clinical effect.
Efficacy
Potency is on ___axis, efficacy on ____axis
x; y
What does the slope of the dose response curve tells us?
How many receptors must be occupied to elicit a clinical effect.
Dose response curve from multiple patients to learn abou tthe
individual variability of each patient.
Measure of potency 2
ED 50 and E90
The curve shifts to left meaning as far as affinity , potency , dose
Increase affinity for receptor, HIGHER POTENCY, lower dose required
The curve shifts to right meaning as far as affinity , potency , dose
Decrease affinity for receptor, LOWER POTENCY, Higher dose required
The height of the plateau on the y-axis represents
efficacy
Higher plateau means _____efficacy
Greater
Lower plateau means _______ efficacy
Lower
A steep slope on the dose-response curve implies
Most of the receptors must be occupied before we observe the clinical response.
Once the effect is observed, small increase in the dose can have a
Profound clinical effect.
Medications with steep slope
NMB and inhaled anesthetics.
A drugs that binds to a receptor follows which law?
LAW of mass action
There is rate constant for
Drug binding and a rate constant for dissociation from the receptor.
Remember that efficacy is measured by the
height of the y-axis on the dose response curve.
Mimics an endogenous ligand
agonist
Instructs the receptor to produce its maximal response
A full agonist
Different drugs may produce the same clinical effect but each may require a different dose to do so. this is difference in
potency
Continuous administration of an AGONIST may cause (UP or down)
DOWN=REGULATION of the target receptors.
Examples of full agonist at the beta receptor
NE