Antivirals: Influenza

Question 1

Amantadine
Rimantadine

• Class
• MOA
• AE

Answer 1

• Class: Adamantanes
• Influenza A
• MOA: Inhibit uncoating of the viral RNA by interfering with the function of M2/ block acidification of lysosomal fusion
• AE: anticholinergic

Question 2

Baloxivir

• MOA
• AE

Answer 2

MOA: Inhibits the influenza specific cap endonuclease

One dose therapy for both influenza A& B

High rates of resistant virus seen in patients treated

Question 3

Oseltamivir

-MOA

Answer 3

MOA: Influenza binds to cells via the hemaglutinin which binds to sialic acid –> Inhibition of neuraminidase activity decreases release of virus from infected cells, increase formation of viral aggregates and decrease viral speed

Active against Influenza A & B

Question 4

Tenofivir

• MOA
• AE

Answer 4

MOA: Nucleoside reverse transcriptase inhibitors

Hep B, HIV

AE: Major toxicities include abnormalities of calcium & phosphate, increased bone fragility, possible renal dysfunction

Question 5

Entecavir

• Class:
• MOA:

Answer 5

Nucleoside analogs

Most commonly used against Hepatitis B

No anti-HIV activity

Question 6

Telbivudine

Answer 6

Nucleoside analogs

work against Hep B

Question 7

NS3 Protease Inhibitors

Answer 7

Hep C

bosePRavir, telaPRavir, simePRavir

Question 8

NS5B RNA-dependent RNA poly inhibitor, nucleoside based

NS5B RNA-dependent RNA poly inhibitor, non - nucleoside based

Answer 8

sofosBuvir

dasaBuvir

NS5B inhibitors can be coupled w/ NS5A inhibitors in order to treat Hep C

Question 9

NS5A- RNA binding and assembly replication complex inhibitors

Answer 9

LedipAsvir

daclatAsvir

Question 10

SimePRevir

Answer 10

Protease inhibitors

Question 11

• Class: Adamantanes
• Influenza A
• MOA: Inhibit uncoating of the viral RNA by interfering with the function of M2/ block acidification of lysosomal fusion
• AE: anticholinergic

Answer 11

Amantadine
Rimantadine

• Class
• MOA
• AE

Question 12

MOA: Inhibits the influenza specific cap endonuclease

One dose therapy for both influenza A& B

High rates of resistant virus seen in patients treated

Answer 12

Baloxivir

• MOA
• AE

Question 13

MOA: Influenza binds to cells via the hemaglutinin which binds to sialic acid –> Inhibition of neuraminidase activity decreases release of virus from infected cells, increase formation of viral aggregates and decrease viral speed

Active against Influenza A & B

Answer 13

Oseltamivir

-MOA

Question 14

MOA: Nucleoside reverse transcriptase inhibitors

Hep B, HIV

AE: Major toxicities include abnormalities of calcium & phosphate, increased bone fragility, possible renal dysfunction

Answer 14

Tenofivir

• MOA
• AE

Question 15

Nucleoside analogs

Most commonly used against Hepatitis B

No anti-HIV activity

Answer 15

Entecavir

• Class:
• MOA:

Question 16

Nucleoside analogs

work against Hep B

Answer 16

Telbivudine

Question 17

Hep C

bosePRavir, telaPRavir, simePRavir

Answer 17

NS3 Protease Inhibitors

Question 18

sofosBuvir

dasaBuvir

NS5B inhibitors can be coupled w/ NS5A inhibitors in order to treat Hep C

Answer 18

NS5B RNA-dependent RNA poly inhibitor, nucleoside based

NS5B RNA-dependent RNA poly inhibitor, non - nucleoside based

Question 19

LedipAsvir

daclatAsvir

Answer 19

NS5A- RNA binding and assembly replication complex inhibitors

Question 20

Protease inhibitors

Answer 20

SimePRevir