Antimalarial COPY Flashcards
Chloroquine
MOA:
MOR:
AE:
MOA: Links and inhibits haemoglobin, therefore blocking detoxification
MOR: Mutation of gene, Pfcrt, which encodes a transmembrane protein in the parasite’s food vacuole
AE:
- Retinal degredation
- Skin itching in West Africans
- Hypotension, heart block , cardiac arrest
- Suicide attempts
-Drug of choice for area of the world w/ no chloroquine resistance
Mefloquine
-AE
-Active against most strains of chloroquine - resistant P. falciparum
AE:
- Decreased coordination–> important for pilots
- worsen psychiatric disorders–> depression
use with caution in patients using beta blocker
Quinine
AE:
AE:
- N/V
- tinnitus
- distrubed vision
- bizarre ideation
- nightmares
- wonder drug from rainforest
- do NOT use for restless leg syndrome
- Part of family rubiaceae: coffee, ipecac, quinine from cinchona
Primaquine
Activity against RBC stages of malaria
Active against P. vivax
W/ clindamycin = 2nd choice treatment for pneumonia in transplant patients
Malarone/ Proguanil
-MOA
MOA: inhibitor of electron transport, cytochrome B
Approved for prevention and treatment of malaria
$8.60 per pill/ has to be taken everyday
Doxycycline
Active against all strains of malaria
MOA: Links and inhibits haemoglobin, therefore blocking detoxification
MOR: Mutation of gene, Pfcrt, which encodes a transmembrane protein in the parasite’s food vacuole
AE:
- Retinal degredation
- Skin itching in West Africans
- Hypotension, heart block , cardiac arrest
- Suicide attempts
-Drug of choice for area of the world w/ no chloroquine resistance
Chloroquine
MOA:
MOR:
AE:
-Active against most strains of chloroquine - resistant P. falciparum
AE:
- Decreased coordination–> important for pilots
- worsen psychiatric disorders–> depression
use with caution in patients using beta blocker
Mefloquine
-AE
AE:
- N/V
- tinnitus
- distrubed vision
- bizarre ideation
- nightmares
- wonder drug from rainforest
- do NOT use for restless leg syndrome
- Part of family rubiaceae: coffee, ipecac, quinine from cinchona
Quinine
AE:
Activity against RBC stages of malaria
Active against P. vivax
W/ clindamycin = 2nd choice treatment for pneumonia in transplant patients
Primaquine
MOA: inhibitor of electron transport, cytochrome B
Approved for prevention and treatment of malaria
$8.60 per pill/ has to be taken everyday
Malarone/ Proguanil
-MOA
Active against all strains of malaria
Doxycycline
