Anti-protozoal COPY Flashcards
Pentamidine
AE:
Renal dysfunction
Hypotension
Damage to pancreas: Hypoglycemia –> diabetes
Antibiotic spectrum: P. jiroveci, Trypanosomes, Leishmania
Not well absorbed
Given to AIDS patients w/ allergies to sulfa drugs
Metronidazole
Treat C.diff
Tinidazole
Active against anaerobic bacteria
-alt. to. metronidazole and for amoebic dysentery
Nitazoxanide
MOA: Unknown but could be related to inhibition of pyruvate: ferredoxin oxidoreductase
First and only drug approved for treatment for cryptosporidiosis
Used for liquid treatment of diarrhea caused by C.parvum & G.lamblia
Active against protozoa & helminths
Active against anaerobic & microaerophilic bacteria against rotavirus, influenza, hep C
Iodoquinol
MOA: Kills amoebic cysts in intestinal lumen
Recommended as followup after metronidazole in patients w/ invasive amoebic disease
Alt. Medicine: paromomycin
Bismuth
- Anti parasitic & diarrheal
- Travel diarrhea
AE:
Renal dysfunction
Hypotension
Damage to pancreas: Hypoglycemia –> diabetes
Antibiotic spectrum: P. jiroveci, Trypanosomes, Leishmania
Not well absorbed
Given to AIDS patients w/ allergies to sulfa drugs
Pentamidine
Treat C.diff
Metronidazole
Active against anaerobic bacteria
-alt. to metronidazole and for amoebic dysentery
Tinidazole
MOA: Unknown but could be related to inhibition of pyruvate: ferredoxin oxidoreductase
First and only drug approved for treatment for cryptosporidiosis
Used for liquid treatment of diarrhea caused by C.parvum & G.lamblia
Active against protozoa & helminths
Active against anaerobic & microaerophilic bacteria against rotavirus, influenza, hep C
Nitazoxanide
MOA: Kills amoebic cysts in intestinal lumen
Recommended as followup after metronidazole in patients w/ invasive amoebic disease
Alt. Medicine: paromomycin
Iodoquinol
- Anti parasitic & diarrheal
- Travel diarrhea
Bismuth
