Anti-helminthics COPY

Question 1

Mebendazole

Answer 1

MOA: Inhibits microtubule function
MOR: Mutation in beta - tubulin

-Formerly main drug of choice for most intestinal round worms

Question 2

Albendazole

Answer 2

MOA: inhibitory effect on tubulin polymerization

Multiple doses need to needed to eradicate whipworm
One dose for other worms

Question 3

Pyrantel

Answer 3

Used to be available as prescription, now OTC

-All intestinal round worms covered by pyrantel and mebendazole

Question 4

Ivermectin

Answer 4

MOA: against arthropods

-Scabies: use w/ topical treatments

Question 5

Praziquantel

-MOA

Answer 5

MOA: Opens Ca channels, result in tetanic contraction of worms and vacuolization of the integument

• Kills only adult tapeworns
• Skin invading cercariae and larval schitosomes are not affected

Question 6

MOA: Inhibits microtubule function
MOR: Mutation in beta - tubulin

-Formerly main drug of choice for most intestinal round worms

Answer 6

Mebendazole

Question 7

MOA: inhibitory effect on tubulin polymerization

Multiple doses need to needed to eradicate whipworm
One dose for other worms

Answer 7

Albendazole

Question 8

Used to be available as prescription, now OTC

-All intestinal round worms covered by pyrantel and mebendazole

Answer 8

Pyrantel

Question 9

MOA: against arthropods

-Scabies: use w/ topical treatments

Answer 9

Ivermectin

Question 10

MOA: Opens Ca channels, result in tetanic contraction of worms and vacuolization of the integument

• Kills tapeworns
• Skin invading cercariae and larval schitosomes are not affected

Answer 10

Praziquantel

-MOA